{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:10:12Z","timestamp":1721261412890},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myelodysplastic Syndromes (MDS) and Chronic Myelomonocytic Leukemia (CMML) are clonal myeloid malignancies, characterized by bone marrow failure leading to cytopenias (and possible myeloproliferation for CMML) and a high propensity to evolve to Acute Myeloid Leukemia (AML).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective and Methods<\/jats:title><jats:p>The aim of our retrospective study was to evaluate the clinical and hematological features; the prevalence of MDS subtypes, R\u2010IPSS, and the outcome of 106 Armenian MDS\/CMML patients diagnosed over the 2008\u20132020 period in a single Armenian Hematology center and compare them to French MDS patients included in the GFM registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age in the Armenian cohort was 64\u2009years (range 19\u201384) and 55% were males. The main MDS subtypes were MDS\u2010MLD (29.2%) and MDS\u2010SLD (27.3%), the least frequent was del 5q (0.9%). By comparison, a higher prevalence of MDS\u2010MLD, MDS\u2010EB2, and MDS\u2010RS was found in the French cohort. Armenian patients\u2019 cohort generally had poor access to standard MDS treatment and 42.3% of the patients were transfusion dependent. Overall survival, however, did not significantly differ between Armenian and French cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study stresses issues regarding epidemiology, access to diagnosis, difficulties of risk stratification, and access to treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14115","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T04:30:27Z","timestamp":1697085027000},"page":"296-300","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MDS<\/scp>\/<scp>CMML<\/scp> from resource\u2010limited region: Characteristics and comparison to tertiary reference <scp>European<\/scp> center"],"prefix":"10.1111","volume":"112","author":[{"given":"Anna","family":"Sevoyan","sequence":"first","affiliation":[{"name":"Department of Hematology H\u00f4pital of Hematology  Yerevan Armenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ars\u00e8ne","family":"Mekinian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne and Inflammation\u2010Immunopathology\u2010Biotherapy Department (DHU i2B) H\u00f4pital Saint\u2010Antoine  Paris France"},{"name":"French Armenian research center  Yerevan Armenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatiha","family":"Chermat","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Saint\u2010Louis Assistance Publique des H\u00f4pitaux de Paris (AP\u2010HP)  Paris France"},{"name":"INSERM U944 Institut de Recherche Saint\u2010Louis (IRSL) and Universit\u00e9 de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Ad\u00e8s","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Saint\u2010Louis Assistance Publique des H\u00f4pitaux de Paris 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