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We performed various comparative analyses of all patients and subgroups with and without infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one adults mainly received CAR T\u2010cell therapy for acute leukaemia (53%) and lymphoma (33%). We documented a total of 77 infections in 47 (52%) patients, 37 (48%) during the initial neutropenic phase and 40 (52%) during the non\u2010neutropenic phase. Infections during the neutropenic phase were mainly due to bacterial (29, 78%): catheter infections (11 [38%] cases), endogenous source (5 [17%]), and <jats:italic>Clostridioides difficile<\/jats:italic> (5 [17%]). Patients receiving corticosteroids after CAR T\u2010cell therapy had a higher risk of endogenous infection (100% vs. 16%; <jats:italic>p<\/jats:italic>\u2009=\u2009.006). During the non\u2010neutropenic phase, bacterial infections remained very frequent (24, 60%), mainly with catheter source (8, 33%). Respiratory tract infections were common (17, 43%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Infections after CAR T\u2010cell therapy were frequent. During the neutropenic phase, it is essential to prevent nosocomial infections and balance the use of antibiotics to lower endogenous bacteraemia and Clostridial infection rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14122","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:59:05Z","timestamp":1698281945000},"page":"371-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving <scp>CAR<\/scp> T\u2010cell therapy"],"prefix":"10.1111","volume":"112","author":[{"given":"Nicol","family":"Garcia\u2010Pouton","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona 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Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-6318","authenticated-orcid":false,"given":"Tommaso Francesco","family":"Aiello","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1533-5626","authenticated-orcid":false,"given":"Patricia","family":"Monzo\u2010Gallo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lopera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Hospital Clinic of Barcelona\u2010IDIBAPS University of Barcelona  Barcelona 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