{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:22:25Z","timestamp":1788960145610,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>There are significant disparities in outcomes among Hispanic patients with acute lymphoblastic leukemia (ALL). Recent studies have demonstrated favorable outcomes of pegaspargase\u2010containing ALL regimens (PEG\u2010CAR) in young adults however, outcomes in Hispanic ethnicity continue to be underreported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated outcomes of newly diagnosed, adult B\u2010cell ALL Hispanic and non\u2010Hispanic patients consecutively treated with a PEG\u2010CAR or HyperCVAD between January 2011 and November 2022. The primary endpoint was event\u2010free survival (EFS) while secondary endpoints included cumulative incidence of relapse and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 105 included patients, 48 (45.7%) were treated with a PEG\u2010CAR and 57 (54.3%) with HyperCVAD. Median age was 38\u2009years (range, 18\u201375\u2009years), 61% were Hispanic, and 35.2% had poor\u2010genetic risk. Hispanic patients demonstrated significantly worse 5\u2010year EFS with a PEG\u2010CAR compared to that seen with HyperCVAD (HR, 2.58; 95% CI, 1.32\u20135.04; <jats:italic>p<\/jats:italic>\u2009=\u2009.006) whereas non\u2010Hispanic patients had better outcomes with PIR (52.4% vs. 42.0%). Hispanic ethnicity (<jats:italic>p<\/jats:italic>\u2009=\u2009.015) and male sex (<jats:italic>p<\/jats:italic>\u2009=\u2009.019) were independent predictors for poor OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hispanic patients with B\u2010cell ALL had worse EFS with a PEG\u2010CAR as compared with HyperCVAD. Future studies will aim to confirm these findings and establish a tailored treatment approach for this high\u2010risk population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14125","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T06:54:24Z","timestamp":1699340064000},"page":"392-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>HyperCVAD<\/scp> versus pegaspargase\u2010containing regimens for <scp>Hispanic<\/scp> adults with newly diagnosed <scp>B<\/scp>\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-1345","authenticated-orcid":false,"given":"Benjamin J.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"},{"name":"Department of Clinical Pharmacy Practice, School of Pharmacy &amp; Pharmaceutical Sciences University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-2490","authenticated-orcid":false,"given":"Shawn P.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"},{"name":"Department of Clinical Pharmacy Practice, School of Pharmacy &amp; Pharmaceutical Sciences University of California  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-5243","authenticated-orcid":false,"given":"Jean","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-4219","authenticated-orcid":false,"given":"Alexandre","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"},{"name":"Department of Clinical Pharmacy Practice, School of Pharmacy &amp; Pharmaceutical Sciences University of California  Irvine California USA"},{"name":"Department of Medicine, Division of Hematology Oncology, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-3271","authenticated-orcid":false,"given":"Stefan O.","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-1814","authenticated-orcid":false,"given":"Deepa","family":"Jeyakumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-6079","authenticated-orcid":false,"given":"Angela G.","family":"Fleischman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology Oncology, Chao Family Comprehensive Cancer Center University of California Irvine Health  Orange California 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