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Currently, B\u2010cell maturation antigen (BCMA) is the most targeted surface protein due to its ubiquitous expression on plasma cells, with increasing expression of this essential transmembrane protein on malignant plasma cells as patients develop more advanced disease. This review will explore the earliest CAR\u2010T trials in myeloma, discuss important issues involved in CAR\u2010T manufacturing and processing, as well as review current clinical trials that led to the approval of the two commercially available CAR\u2010T products, Idecabtagene vicleucel and ciltacabtagene autoleucel. The most recent data from trials investigating the use of CAR\u2010T as an earlier line of therapy will be presented. Finally, the problem of relapses after CAR\u2010T will be presented, including several theories as to why CAR\u2010T therapies fail and possible clinical caveats. The next generation of MM\u2010specific CAR\u2010T will likely include new targets such as G\u2010protein\u2010coupled receptor class C, Group 5, member D (GPRC5D) and signaling lymphocyte activation molecular Family 7 (SLAMF7). The role of CAR\u2010T in the treatment of MM will undoubtedly increase exponentially in the next decade.<\/jats:p>","DOI":"10.1111\/ejh.14145","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T16:15:51Z","timestamp":1702656951000},"page":"493-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Update on the current and future use of <scp>CAR\u2010T<\/scp> to treat multiple myeloma"],"prefix":"10.1111","volume":"112","author":[{"given":"Zhubin","family":"Gahvari","sequence":"first","affiliation":[{"name":"Division of Hematology, Medical Oncology, and Palliative Care, Department of Medicine School of Medicine and Public Health, University of Wisconsin\u2010Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brunner","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical Oncology, and 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