{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:40:44Z","timestamp":1792014044036,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hemorrhagic cystitis (HC) is a highly impacting complication in allogeneic hematopoietic stem cell transplantation (HSCT), occurring in 12%\u201337% of patients. The impact of transplant\u2010 and patient\u2010specific variables has been described, with a possible role for JCV and BKV, which may be cooperating with cytomegalovirus (CMV). Here, we analyze 134 letermovir\u2010exposed, CMV\u2010free patients, treated with the same cyclophosphamide\u2010based graft\u2010versus\u2010host disease (GVHD) prophylaxis, describing risk factors for HC. The overall incidence of HC was 23%. Patients with HLA mismatched transplant, higher comorbidity score, and receiving three alkylating agents with TBF (thiotepa, busulfan, and fludarabine) conditioning regimen had a higher risk of HC in multivariate analysis (OR: 4.48, 6.32, and 1.32, respectively). A HC\u2010score including male gender, TBF conditioning, and HLA\u2010mismatch stratifies the risk of HC in the first 100\u2009days after HSCT. The role of BKV and JCV was not highly impacting in those patients, suggesting a possible synergistic effect between CMV and JCV in causing HC. HC can be interpreted as the combination of patient\u2010related factors, chemotherapy\u2010related toxicities\u2014especially due to alkylating agents\u2014and immunological elements.<\/jats:p>","DOI":"10.1111\/ejh.14147","type":"journal-article","created":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T11:54:18Z","timestamp":1704542058000},"page":"577-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation in a letermovir\u2010exposed <scp>CMV<\/scp>\u2010free population receiving <scp>PTCy<\/scp>"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-916X","authenticated-orcid":false,"given":"Eugenio","family":"Galli","sequence":"first","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-1273","authenticated-orcid":false,"given":"Elisabetta","family":"Metafuni","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-7696","authenticated-orcid":false,"given":"Carlo","family":"Gandi","sequence":"additional","affiliation":[{"name":"UOC Clinica Urologica, Dipartimento di Scienze Mediche e Chirurgiche Addominali ed Endocrino Metaboliche, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-8554","authenticated-orcid":false,"given":"Maria Assunta","family":"Limongiello","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1382-5496","authenticated-orcid":false,"given":"Sabrina","family":"Giammarco","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mattozzi","sequence":"additional","affiliation":[{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-218X","authenticated-orcid":false,"given":"Rosaria","family":"Santangelo","sequence":"additional","affiliation":[{"name":"UOC Microbiologia, Dipartimento di scienze di laboratorio e infettivologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Sezione di Microbiologia e Virologia, Dipartimento di Scienze biotecnologiche di base, cliniche intensivologiche e perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bacigalupo","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-5298","authenticated-orcid":false,"given":"Federica","family":"Sor\u00e0","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-1587","authenticated-orcid":false,"given":"Patrizia","family":"Chiusolo","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2426-3465","authenticated-orcid":false,"given":"Simona","family":"Sica","sequence":"additional","affiliation":[{"name":"UOC Ematologia e Trapianto di cellule staminali emopoietiche, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12629"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30107-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705030"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.926757"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/16.1.142"},{"key":"e_1_2_11_7_1","article-title":"Haemorrhagic cystitis in haematopoietic stem cell transplantation (HSCT): a prospective observational study of incidence and management in HSCT centres within the GITMO network (Gruppo Italiano Trapianto Midollo Osseo)","volume":"8","author":"Gargiulo G","year":"2014","journal-title":"Ecancermedicalscience"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.142"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.193"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jgid.jgid_139_21"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2802.211727"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280590900391"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010023\u201005121\u20109"},{"key":"e_1_2_11_14_1","unstructured":"DETERMINA.Gazzetta Ufficiale Classificazione del medicinale per uso umano \u00abPrevymis\u00bb ai sensi dell'articolo 8 comma 10 della legge 24 dicembre 1993 n. 537. 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