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A total of 33 (73.3%), 5 (11.1%), and 6 (13.3%) patients had Burkitt lymphoma\/leukemia, diffuse large B\u2010cell lymphoma, and aggressive mature B\u2010NHL, not otherwise specified, respectively. Ten (22.2%) and 21 (46.7%) patients had central nervous system disease and leukemic disease, respectively. The median follow\u2010up period was 47.5\u2009months. Three\u2010year event\u2010free survival and overall survival were 97.7% (95% confidence interval, 84.9\u201399.7) and 100%, respectively. The only event was relapse, which occurred in a patient with diffuse large B\u2010cell lymphoma. Seven patients (15.6%) developed Grade 4 or higher non\u2010hematologic adverse events. Febrile neutropenia was the most frequent Grade 3 or higher adverse event after the pre\u2010phase treatment, with a frequency of 54.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy and safety of rituximab in combination with LMB chemotherapy in children with high\u2010risk mature B\u2010NHL was observed in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14148","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T12:44:49Z","timestamp":1702989889000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rituximab with standard <scp>LMB<\/scp> chemotherapy in pediatric high\u2010risk mature B\u2010cell non\u2010Hodgkin lymphoma: A report from the <scp>JPLSG B\u2010NHL14<\/scp> trial"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-3196","authenticated-orcid":false,"given":"Tetsuya","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Pediatrics St. Marianna University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-6788","authenticated-orcid":false,"given":"Tomoo","family":"Osumi","sequence":"additional","affiliation":[{"name":"Children's Cancer Center, National Center for Child Health and Development  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-5389","authenticated-orcid":false,"given":"Akiko","family":"Kada","sequence":"additional","affiliation":[{"name":"Clinical Research Center, NHO Nagoya Medical Center  Aichi 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