{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:34:28Z","timestamp":1780479268906,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe cases of Kaposi's sarcoma\u2010associated herpesvirus (KSHV)\u2010associated multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL) in patients with HIV from a large, safety\u2010net hospital system in Dallas, Texas, USA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review of patients with HIV\u2010associated PEL and\/or MCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve patients with PEL and 10 patients with MCD were identified. All patients were male and 17 of 20 were men who have sex with men; 66.7% of PEL patients and 50% of MCD patients had concurrent KS at the time of diagnosis; 42% of patients with PEL and 20% of patients with MCD died during the follow\u2010up period. We noted improved survival in our cohort compared to previous studies, particularly in our PEL patients with a median survival of 11.4\u2009months compared to 3\u20136\u2010month median survival historically. Median follow\u2010up time for MCD patients was 17.5\u2009months. This improved survival is despite suboptimal antiretroviral therapy (ART) adherence at diagnosis, with only 50% of patients on ART at the time of MCD\/PEL diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data highlight the importance of early recognition of PEL and MCD, and the larger\u2010scale efforts needed to better understand the pathogenetic drivers of clinical outcomes in patients affected by KSHV\u2010related diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14163","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:18:53Z","timestamp":1703809133000},"page":"723-730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes in\n                    <scp>Kaposi's<\/scp>\n                    sarcoma\u2010associated herpesvirus \u2010associated primary effusion lymphoma and multicentric\n                    <scp>Castleman's<\/scp>\n                    disease in patients with human immunodeficiency virus (\n                    <scp>HIV<\/scp>\n                    ) in a safety\u2010net hospital system"],"prefix":"10.1111","volume":"112","author":[{"given":"Melanie","family":"Lopez","sequence":"first","affiliation":[{"name":"Department of Undergraduate Medical Education University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Kainthla","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Parkland Health  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Lazarte","sequence":"additional","affiliation":[{"name":"Parkland Health  Dallas Texas USA"},{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5638-4371","authenticated-orcid":false,"given":"Weina","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ank E.","family":"Nijhawan","sequence":"additional","affiliation":[{"name":"Parkland Health  Dallas Texas USA"},{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-1485","authenticated-orcid":false,"given":"Sheena","family":"Knights","sequence":"additional","affiliation":[{"name":"Parkland Health  Dallas Texas USA"},{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201003\u2010791426"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.694075"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3589"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003959"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.4.1276.bloodjournal8641276"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253\u2010013\u20109619\u2010z"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020004058"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000003155"},{"issue":"4","key":"e_1_2_12_10_1","article-title":"High seroprevalence of Kaposi sarcoma\u2010associated herpesvirus in men who have sex with men with HIV in the southern United States. 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