{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:33:40Z","timestamp":1788910420843,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy has become a commercially available treatment option for relapsed or refractory (r\/r) diffuse large B\u2010cell lymphoma (DLBCL) with two or more lines of prior therapies, and recently for high\u2010risk r\/r DLBCL with one prior line of therapy. The successful development of CAR T\u2010cell therapy for multiple relapsed DLBCL has led to a boom in subsequent trials that investigated its utility in patients with other r\/r B\u2010cell lymphoma subtypes. However, CAR T\u2010cell therapy is a multistep process that includes leukapheresis and manipulation which take several weeks. Therefore, patients with rapidly progressing or bulky disease may not be able to complete the therapeutic regimen involving CAR T\u2010cell products. This raises the question of the generalizability of the results of pivotal studies to the entire population. In this review, we summarize the development of CAR\u2010T cell therapy for B\u2010cell lymphoma and discuss strategies to further improve the clinical outcomes of this treatment.<\/jats:p>","DOI":"10.1111\/ejh.14166","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T05:43:26Z","timestamp":1704260606000},"page":"662-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Current development of chimeric antigen receptor T\u2010cell therapy for diffuse large B\u2010cell lymphoma and high\u2010grade B\u2010cell lymphoma"],"prefix":"10.1111","volume":"112","author":[{"given":"Nobuhiko","family":"Yamauchi","sequence":"first","affiliation":[{"name":"Department of Hematology Oncology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Koto\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0654-6920","authenticated-orcid":false,"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Koto\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707447"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0297-y"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512073332305"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.1618"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4062"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-769620"},{"issue":"19","key":"e_1_2_15_10_1","first-page":"2307","article-title":"Five\u2010year follow\u2010up of ZUMA\u20101 supports the curative potential of axicabtagene ciloleucel in refractory large B\u2010cell lymphoma","volume":"141","author":"Neelapu SS","year":"2023","journal-title":"Blood"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00375-2"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001304"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006406"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02104"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.05.026"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003092"},{"issue":"4","key":"e_1_2_15_17_1","first-page":"349","article-title":"GLA\/DRST real\u2010world outcome analysis of CAR T\u2010cell therapies for large B\u2010cell lymphoma in Germany","volume":"140","author":"Bethge WA","year":"2022","journal-title":"Blood"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004162"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009019"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01699-6"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02103"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01969-y"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116133"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2116596"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00662-6"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3136"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00339-4"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2301665"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013289"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102443"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00456-w"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206913"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01725"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01739-2"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006770"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02143"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01731-4"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02079"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01436-0"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005807"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.12.005"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14166","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.14166","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:58:33Z","timestamp":1772960313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.14166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ejh.14166"],"URL":"https:\/\/doi.org\/10.1111\/ejh.14166","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"2023-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}