{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:45:45Z","timestamp":1789677945295,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009527","name":"Statens Serum Institut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (MF) are myeloproliferative neoplasms (MPN). Inflammation is involved in the initiation, progression, and symptomology of the diseases. The gut microbiota impacts the immune system, infection control, and steady\u2010state hematopoiesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed the gut microbiota of 227 MPN patients and healthy controls (HCs) using next\u2010generation sequencing. We expanded our previous results in PV and ET patients with additional PV, pre\u2010MF, and MF patients which allowed us to compare MPN patients collectively, MPN sub\u2010diagnoses, and MPN mutations (separately and combined) vs. HCs (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200942) and compare within MPN sub\u2010diagnoses and MPN mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MPN patients had a higher observed richness (median, 245 [range, 49\u2013659]) compared with HCs (191.5 [range, 111\u2013300;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003]) and a lower relative abundance of taxa within the\n                      <jats:italic>Firmicutes<\/jats:italic>\n                      phylum; for example,\n                      <jats:italic>Faecalibacterium<\/jats:italic>\n                      (6% vs. 14%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). The microbiota of\n                      <jats:italic>CALR<\/jats:italic>\n                      \u2010positive patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200930) resembled that of HCs more than that of patients with\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009177). In\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      \u2010positive patients, only minor differences in the gut microbiota were observed between MPN sub\u2010diagnoses, illustrating the importance of this mutation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The gut microbiota in MPN patients differs from HCs and is driven by\n                      <jats:italic>JAK2V617F<\/jats:italic>\n                      , whereas the gut microbiota in\n                      <jats:italic>CALR<\/jats:italic>\n                      patients resembles HCs more.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14169","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T08:38:53Z","timestamp":1705394333000},"page":"776-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<i>JAK2V617F<\/i>\n                    drives gut microbiota differences in patients with myeloproliferative neoplasms"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-0555","authenticated-orcid":false,"given":"Christina Schjellerup","family":"Eickhardt\u2010Dalb\u00f8ge","sequence":"first","affiliation":[{"name":"The Regional Department of Clinical Microbiology University Hospital of Region Zealand  Slagelse Denmark"},{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Bacteria, Parasites &amp; 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Fungi Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Lilje","sequence":"additional","affiliation":[{"name":"Department of Bacteria, Parasites &amp; Fungi Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-5928","authenticated-orcid":false,"given":"Morten Kranker","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6767-0226","authenticated-orcid":false,"given":"Lasse","family":"Kj\u00e6r","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-0440","authenticated-orcid":false,"given":"Sarah Friis","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-3099","authenticated-orcid":false,"given":"Trine Alma","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0097-7826","authenticated-orcid":false,"given":"Vibe","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-1595","authenticated-orcid":false,"given":"Anders Lindholm","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-4375","authenticated-orcid":false,"given":"Christina","family":"Ellervik","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Pathology Harvard Medical School  Boston Massachusetts USA"},{"name":"Department of Data and Data Support Region Zealand  Sor\u00f8 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6725-7850","authenticated-orcid":false,"given":"Lars R\u00f8nn","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Health Technology Technical University of Denmark  Lyngby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6721-4917","authenticated-orcid":false,"given":"Jens J\u00f8rgen Elmer","family":"Christensen","sequence":"additional","affiliation":[{"name":"The Regional Department of Clinical Microbiology University Hospital of Region Zealand  Slagelse Denmark"},{"name":"Institute of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-5748","authenticated-orcid":false,"given":"Xiaohui Chen","family":"Nielsen","sequence":"additional","affiliation":[{"name":"The Regional Department of Clinical Microbiology University Hospital of Region Zealand  Slagelse Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-8032","authenticated-orcid":false,"given":"Hans Carl","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Zealand University Hospital  Roskilde Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6079-6643","authenticated-orcid":false,"given":"Anna C\u00e4cilia","family":"Ingham","sequence":"additional","affiliation":[{"name":"Department of Bacteria, Parasites &amp; 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