{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:15:06Z","timestamp":1772982906082,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Early death (ED) is the unsolved issue of acute promyelocytic leukemia (APL). The disseminated intravascular coagulation (DIC) score has been proposed as a marker of bleeding and death in APL; whether its temporal evolution predicts outcomes in APL is unknown. We evaluated whether an increasing score 48\u2009h after diagnosis associates with ED.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective, single\u2010center study, including patients with newly diagnosed APL between 2000 and 2023, treated with all\u2010transretinoic acid (ATRA) plus anthracycline or arsenic trioxide (ATO). \u201cDIC score worsening\u201d was defined as \u22651 point increase in the score after 48\u2009h, and ED as death within 30\u2009days of diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010six patients were included, with median age of 46\u2009years (17\u201382). ED patients (26.7%) more frequently had age\u2009&gt;60\u2009years and worsening DIC score after 48\u2009h. These were also the only predictors of ED identified in both univariate and multivariate (OR 4.18,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.011; OR 7.8,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.005, respectively) logistic regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This is the first study on DIC score evolution in APL\u2014a worsening DIC score 48\u2009h after diagnosis is a strong independent predictive factor of ED. We propose a reduction of the DIC score from diagnosis as a new treatment goal in APL care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14177","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T05:59:13Z","timestamp":1706853553000},"page":"840-844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Disseminated intravascular coagulation score evolution in 48\u2009h predicts early death in acute promyelocytic leukemia patients"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-2299","authenticated-orcid":false,"given":"Joana Brioso","family":"Infante","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Hematologia e Transplanta\u00e7\u00e3o de Medula Centro Hospitalar Universit\u00e1rio Lisboa Norte\u2014Hospital de Santa Maria  Lisboa Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa  Lisboa Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u00e7a Vasconcelos","family":"Esteves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia e Transplanta\u00e7\u00e3o de Medula Centro Hospitalar Universit\u00e1rio Lisboa Norte\u2014Hospital de Santa Maria  Lisboa Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Raposo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia e Transplanta\u00e7\u00e3o de Medula Centro Hospitalar Universit\u00e1rio Lisboa Norte\u2014Hospital de Santa Maria  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Forjaz","family":"de Lacerda","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Hematologia e Transplanta\u00e7\u00e3o de Medula Centro Hospitalar Universit\u00e1rio Lisboa Norte\u2014Hospital de Santa Maria  Lisboa Portugal"},{"name":"Faculdade de Medicina da Universidade de Lisboa  Lisboa Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes  Lisboa Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.78"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.10874"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201004\u2010346437"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010013\u20100478\u2010y"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"30","article-title":"Score de Coagulaci\u00f3n Intravascular Diseminada identifica pacientes con Leucemia Promieloc\u00edtica Aguda con alto riesgo de mortalidad precoz","volume":"103","author":"Infante J","year":"2018","journal-title":"Haematologica"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001280"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616068"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ccm.0000153520.31562.48"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102019\u201001\u2010894980"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2007.02313.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ejh.14177","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:58:32Z","timestamp":1772960312000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.14177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,2]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/ejh.14177"],"URL":"https:\/\/doi.org\/10.1111\/ejh.14177","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,2]]},"assertion":[{"value":"2023-10-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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