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We aimed to explore pancreatic sequelae among ALL survivors with and without AAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated pancreatic sequelae in a national cohort of ALL survivors, aged 1\u201345\u2009years at ALL diagnosis treated according to the NOPHO\u2010ALL2008 protocol and included sex\u2010 and age\u2010matched community controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 368 survivors (median follow\u2010up 6.9\u2009years), including 47 survivors with AAP and 369 controls. The p\u2010lipase and p\u2010pancreas\u2010type amylase levels were lower in AAP survivors compared with both non\u2010AAP survivors (Medians: 23\u2009U\/L [IQR 14\u201332] and 18\u2009U\/L [IQR 10\u201325] versus 29 [IQR 24\u201335] and 22 [17\u201328], <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001 and <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and community controls (28\u2009U\/L [IQR 22\u201333] and 21\u2009U\/L [IQR 17\u201326], both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.006). Fecal\u2010elastase was more frequently reduced in AAP survivors compared with non\u2010AAP survivors (7\/31 vs. 4\/144, <jats:italic>p<\/jats:italic>\u2009=\u2009.001). Persisting pancreatic sequelae were found in 15\/47 of AAP survivors and 20\/323 of non\u2010AAP survivors (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), including diabetes mellitus in 2\/39 of AAP survivors and 2\/273 of non\u2010AAP survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ALL survivors with AAP are at increased risk of persisting pancreatic dysfunction and require special attention during follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14189","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T03:11:42Z","timestamp":1707880302000},"page":"944-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pancreas\u2010related persisting sequelae in <scp>ALL<\/scp> survivors with a history of asparaginase\u2010associated pancreatitis: A part of the <scp>ALL\u2010STAR<\/scp> study"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-4814","authenticated-orcid":false,"given":"Mette Tiedemann","family":"Skipper","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Birkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Steno Diabetes Center Aarhus Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke Beck","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Copenhagen University Hospital \u2013 Herlev and Gentofte  Herlev Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilie Utke","family":"Rank","sequence":"additional","affiliation":[{"name":"Department of Hematology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Tuckuviene","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peder Skov","family":"Wehner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology H.C. 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