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Our goal was to study the latter treatment with a new dosing regimen in a retrospective\/observational study. In our department, we analyzed the data of AML patients who were unfit for curative high\u2010dose treatment and accepted the medication with a fixed\u2010dose of azacitidin and venetoclax combination (AZA\u2010VEN, 100\u2009mg sc for 7\u2009days\u2014100\u2009mg per os continuously). The primary end point was the overall survival. In total, 55 AML patients received the treatment between OCT\/2019\u2010DEC\/2022. Mean age was 69.4\u2010year (48\u201384), median overall survival was 17.2\u2010month (95% CI, 14.3\u201320.10) Composite CR: (CR\u2009+\u2009CRi) 62%. Side effect CTCAE 3 or higher: neutropenia with fever: 36.4%, anemia: 29.1%, thrombocytopenia: 16.4% and nausea 20%. AZA\u2010VEN combination treatment of our unfit AML patients was found to be a good therapeutic option. The results achieved with significantly lower doses of the fixed dose of AZA\u2010VEN are comparable to the conclusions of the VIALE\u2010A study, and the less severe side effects we have observed are explained by the milder neutropenia of the newly introduced regimen.<\/jats:p>","DOI":"10.1111\/ejh.14213","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T02:45:00Z","timestamp":1713753900000},"page":"183-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fix low dose <scp>venetoclax\u2010azacitidine<\/scp> treatment of unfit <scp>acute myeloid leukemia<\/scp> patients"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5513-5880","authenticated-orcid":false,"given":"Egyed","family":"Miklos","sequence":"first","affiliation":[{"name":"Department of Hematology Somogy County M\u00f3ritz Kaposi General Hospital  Kaposvar 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