{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:03:18Z","timestamp":1747184598619,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are few reports of clinical practice treatment patterns and efficacy in mantle cell lymphoma (MCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively studied a large, multicenter, cohort of patients with MCL diagnosed between 2000 and 2020 in eight institutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>536 patients were registered (73% male, median of 70\u2009years). Front\u2010line treatment was based on high\u2010dose cytarabine, bendamustine, and anthracyclines in 42%, 12%, and 15%, respectively. The median PFS for all patients was 45\u2009months; 68, 34, and 30\u2009months for those who received high\u2010dose cytarabine\u2010based, bendamustine\u2010based and anthracycline\u2010based therapy. 204 patients received second\u2010line. Bendamustine\u2010based treatment was the most common second\u2010line regimen (36% of patients). The median second\u2010line PFS (sPFS) for the entire cohort was 14\u2009months; 19, 24, and 31 for bendamustine\u2010, platinum\u2010, and high\u2010dose cytarabine\u2010based regimens, with broad confidence intervals for these latter estimates. Patients treated with cytarabine\u2010based therapies in the front\u2010line and those with front\u2010line PFS longer than 24\u2009months had a substantially superior sPFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Front\u2010line treatment in this cohort of MCL was as expected and with a median PFS of over 3.5\u2009years. Second\u2010line treatment strategies were heterogeneous and the median second\u2010line PFS was little over 1 year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14219","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T12:09:54Z","timestamp":1714046994000},"page":"218-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Front\u2010line and second\u2010line treatment for mantle cell lymphoma in clinical practice: A multicenter retrospective analysis"],"prefix":"10.1111","volume":"113","author":[{"given":"Minna","family":"Harmanen","sequence":"first","affiliation":[{"name":"University of Eastern Finland, Faculty of Health Sciences Medicine, School of Medicine, Institute of Clinical Medicine  Kuopio 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