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In this study, PtCy was used in 44 patients along with mycophenolate and tacrolimus with HLA matched (29) and mismatched (15) unrelated donors to determine the impact of graft content on outcome; thus, all patients had flow cytometric analysis of their graft content including the number of B cells, NK cells, and various T cell subsets. Higher \u03b3\u03b4 T cell dose was associated with the development of acute GVHD (<jats:italic>p<\/jats:italic>\u2009=\u2009.0038). For PtCy, further studies of the cell product along with further graft manipulation, such as selective \u03b3\u03b4 T cell depletion, could potentially improve outcomes.<\/jats:p>","DOI":"10.1111\/ejh.14221","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T06:49:05Z","timestamp":1715064545000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A prospective study of posttransplant cyclophosphamide for unrelated donor peripheral blood stem cell transplant with special attention to graft content and the impact of a higher \u03b3\u03b4 T cell dose"],"prefix":"10.1111","volume":"113","author":[{"given":"Chetan","family":"Jeurkar","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Kimmel Cancer Center Thomas Jefferson University  Philadelphia Pennsylvania 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