{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:54Z","timestamp":1787014134036,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL151367"],"award-info":[{"award-number":["R01HL151367"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Iron deficiency is the most common extraintestinal sign of colonic neoplasia, including colorectal cancer (CRC) and other lower gastrointestinal pathology. Both upper endoscopy and colonoscopy is usually recommended in the work\u2010up of patients with unexplained iron deficiency, particularly in men and postmenopausal women. As the incidence of early\u2010onset CRC (age &lt;50\u2009years) rises in the United States, there is an increasing need to identify risk predictors to aid in the early detection of CRC. It remains unknown if serum ferritin (SF), and what specific threshold, can be used as a marker to stratify those at risk for CRC and other lower gastrointestinal pathology. In this current review of the literature, we aimed to review guidelines for diagnostic workup of colonic neoplasia in the setting of iron deficiency and examine the association and specific thresholds of SF and risk of CRC by age. Some of the published findings are conflicting, and conclusions specific to younger patients are limited. Though further investigation is warranted, the cumulative findings suggest that SF, in addition to considering the clinical context and screening guidelines, may have potential utility in the assessment of colonic neoplasia.<\/jats:p>","DOI":"10.1111\/ejh.14229","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T02:39:08Z","timestamp":1715913548000},"page":"138-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum ferritin and risk of colonic neoplasia:\n                    <scp>Implications<\/scp>\n                    for the workup and treatment of iron deficiency"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-8216","authenticated-orcid":false,"given":"Adam L.","family":"Urback","sequence":"first","affiliation":[{"name":"Division of Internal Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5379-8202","authenticated-orcid":false,"given":"Kylee","family":"Martens","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-1285","authenticated-orcid":false,"given":"Hannah Stowe","family":"McMurry","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Citti","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5790-4700","authenticated-orcid":false,"given":"Thomas G.","family":"DeLoughery","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-5976","authenticated-orcid":false,"given":"Joseph J.","family":"Shatzel","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Knight Cancer Institute, Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i35.7908"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2016.09.004"},{"issue":"5","key":"e_1_2_13_6_1","first-page":"772","article-title":"Serious gastrointestinal pathology found in patients with serum ferritin values < or\u2009=\u200950 ng\/ml","volume":"93","author":"Lee JG","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20613"},{"issue":"11","key":"e_1_2_13_8_1","first-page":"1094","article-title":"Gastrointestinal evaluation of anaemic patients without evidence of iron deficiency","volume":"20","author":"Powell N","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00168-X"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.21873\/cdp.10196"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_2_13_13_1","unstructured":"Surveillance Research Program National Cancer Institute.An interactive website for SEER cancer statistics [Internet]. 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