{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:03:23Z","timestamp":1747184603178,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Triple\u2010 and quad\u2010refractory multiple myeloma patients usually have an aggressive course and a poor prognosis. Available therapeutic options are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The objective of the current study was to evaluate responses and toxicities of VDTPACE or mCBAD with hematopoietic stem\u2010cell support as a bridge to subsequent therapies in patients with refractory\/relapsed multiple myeloma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen patients were included (11 mCBAD, 2 VDTPACE), and 21\u2009cycles of chemotherapy with hematopoietic stem\u2010cell support were delivered. Mean number of previous therapies was 4.8. Stem cells were infused on a median day 9.9 after chemotherapy. Mean time to neutrophil recovery was 18.2\u2009days in patients receiving the first cycle and 15.9 following subsequent cycles. Before therapy, most patients were in PD (77%), PR (15%), or VGPR (8%). Following treatment, the best responses achieved were PR (46%), VGPR (46%), and CR (8%). Median overall and progression\u2010free survivals were 17 and 9\u2009months. There has been no case of non\u2010relapse mortality. In the 21\u2009cycles, the main complications were infectious.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intensive chemotherapy can decrease disease burden in patients with relapsed\/refractory MM, and stem\u2010cell support can successfully decrease toxicities and treatment\u2010related mortality associated with these regimens and may be a good bridging option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14257","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:39:27Z","timestamp":1718771967000},"page":"460-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intensive salvage chemotherapy with <scp>VDTPACE<\/scp> or <scp>mCBAD<\/scp> followed by hematopoietic stem\u2010cell support for refractory\/relapsed multiple myeloma"],"prefix":"10.1111","volume":"113","author":[{"given":"Carolina Perrone","family":"Marques","sequence":"first","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Ovigli","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-9212","authenticated-orcid":false,"given":"Mariana Nassif","family":"Kerbauy","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina de Almeida","family":"Silveira","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Helman","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthya Correa","family":"da Silva","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreza Alice Feitosa","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-5310","authenticated-orcid":false,"given":"Nelson","family":"Hamerschlak","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-1945","authenticated-orcid":false,"given":"Leonardo Javier","family":"Arcuri","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplant Department Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"},{"name":"Academic Research Organization Hospital Israelita Albert Einstein  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"585","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00738-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30152-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00357-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0568"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00940"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2203478"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/BLCTT.S327016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19148"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18185"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24954"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-022-05027-y"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.05.001"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404284"},{"issue":"2","key":"e_1_2_8_16_1","article-title":"2101. 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