{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:45:18Z","timestamp":1790635518947,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate characteristics and outcomes of critically ill cancer patients with marked hyperferritinemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010center retrospective analysis comprising cancer patients with a ferritin level &gt;10.000\u2009\u03bcg\/L treated in the intensive care unit (ICU) between 2012 and 2022 was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 117 patients were included in the analysis. The median age was 59\u2009years (range: 15\u201386\u2009years). Females accounted for 48% of cases. 90% of patients had a hematologic malignancy. The median maximum ferritin level was 27.349\u2009\u03bcg\/L (range: 10.300\u2013426.073\u2009\u03bcg\/L). The diagnostic criteria of septic shock were fulfilled in 51% of cases; 31% of patients had hemophagocytic lymphohistiocytosis (HLH) according to the HLH\u20102004 criteria. Mechanical ventilation, renal replacement therapy and the use of vasopressors were necessary in 59%, 35% and 70% of cases, respectively. The ICU, hospital, 90\u2010day and 1\u2010year survival rates were 33.3%, 23.1%, 23.7% and 11.7%. Patients with septic shock had a worse survival than those without septic shock (<jats:italic>p<\/jats:italic>\u2009=\u2009.001); the survival of patients who fulfilled the HLH\u20102004 criteria did not differ from those who did not (<jats:italic>p<\/jats:italic>\u2009=\u2009.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Critically ill cancer patients with marked hyperferritinemia have poor outcomes. The present data may help to make informed decisions for this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14263","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T03:35:13Z","timestamp":1719545713000},"page":"493-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Marked hyperferritinemia in critically ill cancer patients"],"prefix":"10.1111","volume":"113","author":[{"given":"Paul","family":"Liedgens","sequence":"first","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"},{"name":"Krankenhaus Porz am Rhein Department of Internal Medicine  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-8504","authenticated-orcid":false,"given":"Jan\u2010Michel","family":"Heger","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"},{"name":"Mildred Scheel School of Oncology Aachen Bonn Cologne Dusseldorf (MSSO ABCD) Faculty of Medicine and University Hospital Cologne  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noelle","family":"Sieg","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-1560","authenticated-orcid":false,"given":"Jorge","family":"Garcia Borrega","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-7938","authenticated-orcid":false,"given":"Jan\u2010Hendrik","family":"Naendrup","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2700-3717","authenticated-orcid":false,"given":"Florian","family":"Simon","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2886-7306","authenticated-orcid":false,"given":"Wibke","family":"Johannis","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and University Hospital Cologne, Institute for Clinical Chemistry  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-4455","authenticated-orcid":false,"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2351-7294","authenticated-orcid":false,"given":"Alexander","family":"Shimabukuro\u2010Vornhagen","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4766-4651","authenticated-orcid":false,"given":"Matthias","family":"Kochanek","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6432-0981","authenticated-orcid":false,"given":"Boris","family":"B\u00f6ll","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1927-3514","authenticated-orcid":false,"given":"Dennis A.","family":"Eichenauer","sequence":"additional","affiliation":[{"name":"University of Cologne, First Department of Internal Medicine Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10092008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185438"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010192"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(21)00366\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.03.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26668"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004131"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010020\u201002941\u20103"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38690"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201010\u2010602607"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020715"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012764"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010023\u201001434\u20104"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709751"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010020\u201003139\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.03.023"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13837"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30084"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010021\u201004698\u20103"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007953"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T15:17:08Z","timestamp":1728487028000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.14263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/ejh.14263"],"URL":"https:\/\/doi.org\/10.1111\/ejh.14263","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"2024-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}