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These included 30 patients (35.3%) who received PCAB with one additional agent (bortezomib most frequently). Median age of the patients was 65\u2009years (37\u201380), with a median of four (1\u20138) prior lines of therapy. ORR was 37% (CR 4.9%). Median progression free survival and overall survival were 4.4\u2009months (95% CI 3.5\u20136.7) and 7.4\u2009months (95% CI 6.4\u201310.2), respectively. Extramedullary disease (EMD) was associated with shorter survival. Grade 3 or 4 cytopenia and febrile neutropenia occurred in 76.2% and 39.1%, respectively, with six (7.1%) treatment\u2010related mortalities. Median inpatient stay was 3.3\u2009days\/28\u2010day\u2009cycle (IQR 0.6\u201313), and for patients who died, a median of 20.2% of days alive were spent inpatient (IQR 6.4\u201339.1%). Three patients were successfully bridged to CAR T\u2010cell therapy using PCAB, despite being penta\u2010exposed and having EMD. PCAB may be considered as a useful salvage therapy amongst other polychemotherapy regimens in late relapse. Further studies is warranted to investigate and define its role as a bridging therapy to novel therapeutics.<\/jats:p>","DOI":"10.1111\/ejh.14266","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T05:49:09Z","timestamp":1719985749000},"page":"521-529","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A single\u2010day polychemotherapy regimen with proteasome inhibitor combinations for relapsed\/refractory myeloma in the era of novel therapies"],"prefix":"10.1111","volume":"113","author":[{"given":"Eric Wenlong","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bryant","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"King","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipti","family":"Talaulikar","sequence":"additional","affiliation":[{"name":"Department of Haematology ACT Pathology, Canberra Health Services  Canberra Australia"},{"name":"College of Health and Medicine Australian National University  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yen","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Haematology ACT Pathology, Canberra Health Services  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Bryant","sequence":"additional","affiliation":[{"name":"Department of Haematology Liverpool Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Ridha","sequence":"additional","affiliation":[{"name":"Department of Haematology Liverpool Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole Wong","family":"Doo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"},{"name":"Department of Haematology Concord Repatriation General Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Menzies","sequence":"additional","affiliation":[{"name":"Department of Haematology St George Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Haematology Liverpool Hospital  Sydney Australia"},{"name":"School of Clinical Medicine The University of New South Wales  Kensington Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shir Jing","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Haematology St George Hospital  Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Abadir","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Vanguru","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Joshua","sequence":"additional","affiliation":[{"name":"Institute of Haematology Royal Prince Alfred Hospital  Sydney Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Camperdown Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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