{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:31:08Z","timestamp":1793212268255,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to characterise baseline disease and treatment burden in a large population with haemophilia A\/B, both with (HAwI\/HBwI) and without (HA\/HB) inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective, non\u2010interventional explorer6 study included patients \u226512\u2009years old with severe HA, severe\/moderate HB or HAwI\/HBwI of any severity, treated according to local standard of care (excluding previous\/current exposure to concizumab or emicizumab). Baseline characteristics and historical clinical data were collected and patient\u2010reported outcomes, including treatment burden, were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The explorer6 study enrolled 231 patients with haemophilia (84 HAwI\/HBwI) from 33 countries. At baseline, patients with HA\/HB treated with prophylaxis had the lowest median annualised bleeding rates (ABRs; 2.0), irrespective of haemophilia type; of these patients, 27.5% (HA) and 31.4% (HB) had target joints. Patients with HAwI\/HBwI treated episodically reported the highest treatment burden. Of these patients, 28.5% (HAwI) and 25.1% (HBwI) performed sports activities in the month before screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite receiving routine clinical care, historical and baseline information from patients enrolled in explorer6 showed that patients with HA\/HB treated episodically and patients with HAwI\/HBwI had higher ABRs, higher treatment burden and participated in sports less than those with HA\/HB treated with prophylaxis. Emerging treatments could be beneficial in addressing these unmet medical needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14277","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T08:29:49Z","timestamp":1721377789000},"page":"631-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Disease and treatment burden of patients with haemophilia entering the explorer6 non\u2010interventional study"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-4784","authenticated-orcid":false,"given":"Jerzy","family":"Windyga","sequence":"first","affiliation":[{"name":"Department of Hemostasis Disorders and Internal Medicine Laboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine  Warsaw 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