{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T02:37:28Z","timestamp":1787452648923,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>First\u2010line treatment in patients with acute myeloid leukemia (AML) unfit for intensive therapy is the combination of a hypomethylating agent (HMA) with venetoclax (VEN). However, retrospective data confirming the benefits of this regimen outside of clinical trials have shown conflicting results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a multicenter retrospective analysis of outcomes with first\u2010line HMA\u2013VEN versus HMA in AML patients unfit for intensive chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 213 patients were included from three German hospitals (125 HMA\u2013VEN, 88 HMA). Median overall survival in the HMA\u2013VEN cohort was 7.9\u2009months (95% confidence interval [CI], 5.1\u201314.7) versus 4.9\u2009months (3.1\u20137.1) with HMA. After 1\u2009year, 42% (95% CI, 33\u201354) and 19% (12\u201330) of patients were alive, respectively (hazard ratio [HR] for death, 0.64; 95% CI, 0.46\u20130.88). After adjusting for clinical and molecular baseline characteristics, treatment with HMA\u2013VEN remained significantly associated with both prolonged survival (HR, 0.48; 95% CI, 0.29\u20130.77) and time to next treatment (HR, 0.63; 95% CI, 0.47\u20130.85). Patients who achieved recovery of peripheral blood counts had a favorable prognosis (HR for death, 0.52; 95% CI, 0.33\u20130.84).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These data align with findings from the pivotal VIALE\u2010A trial and support the use of HMA\u2013VEN in patients unfit for intensive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14278","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T11:38:39Z","timestamp":1721302719000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Real\u2010world effectiveness of first\u2010line azacitidine or decitabine with or without venetoclax in acute myeloid leukemia patients unfit for intensive therapy"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-0237","authenticated-orcid":false,"given":"Fabian","family":"Acker","sequence":"first","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Chromik","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Tiedjen","sequence":"additional","affiliation":[{"name":"Carreras Leukemia Center, Hematology, Oncology, Immunology Philipps University Marburg, and University Hospital Giessen and Marburg  Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"},{"name":"Frankfurt Cancer Institute (FCI)  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz A Partnership Between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-8934","authenticated-orcid":false,"given":"Jonas B.","family":"Vischedyk","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"},{"name":"Frankfurt Cancer Institute (FCI)  Frankfurt am Main Germany"},{"name":"University Cancer Center Frankfurt (UCT) Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Makowka","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-5942","authenticated-orcid":false,"given":"Julius C.","family":"En\u00dfle","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"},{"name":"Frankfurt Cancer Institute (FCI)  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz A Partnership Between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6562-370X","authenticated-orcid":false,"given":"Khouloud","family":"Kouidri","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0404-7741","authenticated-orcid":false,"given":"Martin","family":"Sebastian","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Steffen","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6570-6125","authenticated-orcid":false,"given":"Thomas","family":"Oellerich","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"},{"name":"Frankfurt Cancer Institute (FCI)  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz A Partnership Between DKFZ and University Hospital Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Serve","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology Goethe University Frankfurt, University Hospital  Frankfurt Germany"},{"name":"Frankfurt Cancer Institute (FCI)  Frankfurt am Main Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Frankfurt\/Mainz A Partnership 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