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We therefore examined HRQOL in older HCS compared to a community sample (CS) and investigated sociodemographic, disease\u2010 and treatment\u2010specific, geriatric, and psychosocial factors associated with reduced HRQOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cancer\u2010register\u2010based cross\u2010sectional comparative study 200 HCS, aged \u226570\u2009years, and 252 persons of an age\u2010 and gender\u2010matched CS completed validated questionnaires including the EORTC QLQ\u2010C30 and EORTC QLQ\u2010ELD14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Older HCS reported a reduced HRQOL in the dimensions of global QOL, physical, role, and social functioning (small clinical significance) and higher symptom burden of fatigue, nausea and vomiting, appetite loss, and poorer mobility compared to the CS (fatigue and mobility with medium, the others with small clinical significance). Perceived disease burden of comorbidities, functional disabilities, psychological distress, and depression showed statistical significance for reduced HRQOL in older HCS in multiple linear regression analysis (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u2009.602, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The screening and treatment of functional limitations and individual symptoms and the integration of a geriatric assessment into oncological practice can help to identify supportive care needs, to implement individualized, patient\u2010centered cancer survivorship care programs and to improve older HCS's HRQOL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14285","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T02:15:11Z","timestamp":1722564911000},"page":"693-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Health\u2010related quality of life in older hematological cancer survivors (70+) compared to older general population\u2014A German cancer\u2010register\u2010based cross\u2010sectional comparative study"],"prefix":"10.1111","volume":"113","author":[{"given":"Florian","family":"Schatz","sequence":"first","affiliation":[{"name":"Department of Medical Psychology and Medical Sociology University Medical Center Leipzig, Comprehensive Cancer Center Central Germany (CCCG)  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Mehnert\u2010Theuerkauf","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and 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