{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:21:38Z","timestamp":1791386498640,"version":"4.3.3"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chimeric antigen receptor T\u2010cell (CAR\u2010T) therapy has shown promise in treating hematologic malignancies, yet its potential cardiotoxic effects require thorough investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aim to conduct a systematic review and meta\u2010analysis to examine the cardiotoxic effects of CAR\u2010T therapy in adults with hematologic malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for studies reporting cardiovascular outcomes, such as arrhythmias, heart failure, and reduced left ventricle ejection fraction (LVEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our analysis of 20 studies involving 4789 patients revealed a 19.68% incidence rate of cardiovascular events, with arrhythmias (7.70%), heart failure (5.73%), and reduced LVEF (3.86%) being the most prevalent. Troponin elevation was observed in 23.61% of patients, while NT\u2010Pro\u2010BNP elevation was observed in 9.4. Subgroup analysis showed higher risks in patients with pre\u2010existing conditions, such as atrial arrhythmia (OR 3.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), hypertension (OR 1.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.002), previous heart failure (OR 3.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003), and coronary artery disease (OR 2.80;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vigilant cardiovascular monitoring is crucial for patients undergoing CAR\u2010T therapy to enhance safety and treatment efficacy.Novelty Statements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14289","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:23:55Z","timestamp":1724340235000},"page":"798-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The cardiotoxic effects of CAR\u2010T cell therapy: An updated systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4023-5970","authenticated-orcid":false,"given":"Roberto A. 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