{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:02:29Z","timestamp":1791946949759,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:00:00Z","timestamp":1723334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Elderly acute myeloid leukemia (AML) patients with poor\u2010risk cytogenetics have a poor outcome with intensive chemotherapy (IC). While Venetoclax (VEN) has changed the outcomes of elderly unfit patients treatment, it is unknown whether it could be effective in poor\u2010risk cytogenetics 60\u201375\u2009years old patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We included 60\u201375\u2010year\u2010old AML patients eligible to allogenic stem cell transplantation (allo\u2010SCT) treated with VEN (combined with azacitidine or with Cladribin and Aracytine) at Institut Paoli Calmettes, between 2020 and 2023 and compared this cohort with patients treated by IC between 2010 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty six patients were treated with VEN (17 in combination with azacitidine and 9 with Cladribin and Aracytine) and 90 were treated with IC. Thirteen patients (50%) had a <jats:italic>TP53<\/jats:italic> mutation. The median time for leucocyte and platelet counts recovery was 26\u2009days (range 0\u2013103) and 26\u2009days (range, 0\u201363). The median duration of the first hospitalization was 32\u2009days (ranges, 7\u201379). The composite response rate was 69% (CR\u2009=\u200950%, CRi\u2009=\u20094%, MLFS\u2009=\u200915%). Allo\u2010SCT could be performed in 42% of cases. Median overall survival (OS) was 7.9\u2009months (20.9\u2009months in the group of patients who transitioned to allo\u2010SCT). We found no difference with the historical cohort of patients treated with IC except a trend toward less lower and upper tract gastro\u2010intestinal (GI) tract infections in the VEN group (respectively 8% vs 26%, <jats:italic>p<\/jats:italic>\u2009=\u2009.06; and 0% vs. 13% <jats:italic>p<\/jats:italic>\u2009=\u2009.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VEN\u2010based treatment was found to be effective in high risk AML can be considered as an alternative to IC in patients aged 60\u201375 with adverse cytogenetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14290","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T03:54:01Z","timestamp":1723434841000},"page":"751-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Venetoclax\u2010based non\u2010intensive induction followed by allogenic stem\u2010cell transplantation in elderly acute myeloid leukemia patients with adverse cytogenetics"],"prefix":"10.1111","volume":"113","author":[{"given":"Amel","family":"Soua","sequence":"first","affiliation":[{"name":"Department of Hematology, Institut Paoli\u2010Calmettes, INSERM UMR 1068, CNRS UMR725, CNRS Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gilhodes","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Institut Paoli\u2010Calmettes  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Iat","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institut Paoli\u2010Calmettes, INSERM UMR 1068, CNRS UMR725, CNRS Aix\u2010Marseille University  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosr","family":"Hicheri","sequence":"additional","affiliation":[{"name":"Department of Hematology, Institut 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