{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:55:33Z","timestamp":1791327333469,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluates the feasibility of using post\u2010transplant cyclophosphamide (PTCY) prophylaxis in allo\u2010hematopoietic cell transplantation (HCT) for adults aged 65 and older. PTCY is increasingly used to prevent graft\u2010versus\u2010host disease (GVHD) across all donor types, but concerns remain about potential risks, especially in older patients. Fifty\u2010seven adults aged 65 or older with hematological malignancies, undergoing their first allo\u2010HCT with PTCY prophylaxis between January 2011 and January 2023 were included. Overall, 94.8% of patients achieved primary engraftment. The median durations for neutrophil and platelet engraftments were 19 and 21\u2009days. The day +30 cumulative incidence of bacterial bloodstream infection was 43.9%. No CMV reactivations occurred within the first 100\u2009days after letermovir implementation. The day +180 cumulative incidences of grade II\u2013IV and III\u2013IV acute GVHD, and the 2\u2010year cumulative incidence of moderate\/severe chronic GVHD were 26.3%, 10.5%, and 4.8%. Eighteen patients (31.6%) relapsed, and 30 (52.6%) died, with relapse (16.4%) and infection (11.5%) being the main causes of death. The estimated 2\u2010year overall survival, non\u2010relapse mortality, cumulative incidence of relapse, and GVHD\u2010free relapse\u2010free survival rates were 45.5%, 27.1%, 33.9%, and 37.0%. Adults aged 70 or older had similar outcomes to those aged 65\u201369. This study confirms the safety and feasibility of PTCY\u2010based allo\u2010HCT in older adults.<\/jats:p>","DOI":"10.1111\/ejh.14291","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T04:25:09Z","timestamp":1723695909000},"page":"765-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of older adults undergoing allogeneic hematopoietic cell transplantation with post\u2010transplant cyclophosphamide based prophylaxis"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5963-274X","authenticated-orcid":false,"given":"Victoria","family":"Murillo","sequence":"first","affiliation":[{"name":"Hematology Department Hospital Cl\u00ednico Universitario Lozano Blesa  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Charry","sequence":"additional","affiliation":[{"name":"Apheresis and Cellular 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