{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:36:20Z","timestamp":1784676980708,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0011\/0028"],"award-info":[{"award-number":["RD16\/0011\/0028"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This retrospective single center study aims to describe changes in the severity and organ\u2010specific distribution of GvHD, by comparing the outcomes of 3 distinct GvHD prophylaxis approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 2012 and June 2022, 226 patients underwent allogeneic hematopoietic stem cell transplantation from HLA\u2010matched or 1\u2010allele mismatched related or unrelated donors. Fifty\u2010eight (26%) received prophylaxis with calcineurin inhibitor in combination with mycophenolate mofetil or a short course of methotrexate (Cohort\u20101), 87 (38%) tacrolimus plus sirolimus (Cohort\u20102), and 81 (36%) post\u2010transplant cyclophosphamide (PTCy) plus tacrolimus (Cohort\u20103).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of grade II\u2010IV aGvHD was 69% vs. 41.4% vs. 27.2%; <jats:italic>p\u2009&lt;<\/jats:italic>\u2009.01. The most significant reduction with PTCy was observed in both stage 3\u20134 skin and lower gastrointestinal (GI) involvement (<jats:italic>p\u2009&lt;<\/jats:italic>\u2009.01). The incidence of moderate\u2010to\u2010severe cGvHD at 12\u2009months was 34.5% vs. 34.5% vs. 6.2%; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01. Moderate\u2010to\u2010severe skin and GI cGvHD was less common after PTCy (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). The 1\u2010year GvHD\u2010free\/relapse\u2010free survival was higher with PTCy (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study indicates that PTCy\u2010based GvHD prophylaxis reduces the frequency and severity of both acute and chronic GvHD, with a notable decrease in severe GI and cutaneous manifestations. The higher GRFS may result in lower GvHD\u2010related mortality, leading to an improved quality of life among survivors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14294","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T04:50:07Z","timestamp":1724043007000},"page":"776-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Severity and organ distribution of graft\u2010versus\u2010host disease with post\u2010transplant cyclophosphamide versus calcineurin inhibitor plus methotrexate\/mycophenolate mofetil or sirolimus in allogenic HLA\u2010matched or single\u2010allele mismatched stem cell transplantation"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-7410","authenticated-orcid":false,"given":"Sara","family":"Redondo","sequence":"first","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu i Sant Pau IIB\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes  Barcelona Spain"},{"name":"Departamento de Medicina Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2994-9055","authenticated-orcid":false,"given":"Irene","family":"Garc\u00eda\u2010Cadenas","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu i Sant Pau IIB\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes  Barcelona Spain"},{"name":"Departamento de Medicina Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-5980","authenticated-orcid":false,"given":"Albert","family":"Esquirol","sequence":"additional","affiliation":[{"name":"Hematology Department, Hospital de la Santa Creu i Sant Pau IIB\u2010Sant Pau and Jos\u00e9 Carreras Leukemia Research Institutes  Barcelona Spain"},{"name":"Departamento de Medicina Universidad Aut\u00f3noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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