{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:40:21Z","timestamp":1790091621077,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To study the cytogenetic characteristics of extramedullary disease (EMD) in patients with multiple myeloma (MM) and their impact on prognosis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with newly diagnosed MM (NDMM) at Peking Union Medical College Hospital (Beijing, China) between June 2007 and December 2019 were recruited for this study. Demographic information, clinical data, fluorescence in situ hybridization (FISH) results of marrow and tissue samples, and survival outcome data were collected.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 439 patients with NDMM were divided into those without EMD (non\u2010EMD,\n n<\/jats:italic>\n \u2009=\u2009339), those with EMD with primary paraosseous plasmacytoma (pEMD\u2010B,\n n<\/jats:italic>\n \u2009=\u200948), those with primary EMD with soft\u2010tissue involvement (pEMD\u2010S,\n n<\/jats:italic>\n \u2009=\u200933), and those with secondary EMD (sEMD,\n n<\/jats:italic>\n \u2009=\u200919). The incidence of EMD was 18.5% (81\/439) at diagnosis and 22.8% (100\/439) throughout the disease course. Comparison of FISH results showed a higher proportion of\n RB1<\/jats:italic>\n deletion (\n n<\/jats:italic>\n \u2009=\u200920; 60.0% vs. 20.0%,\n p<\/jats:italic>\n \u2009=\u2009.013) and\n MYC<\/jats:italic>\n translocation (\n n<\/jats:italic>\n \u2009=\u200912; 44.4% vs. 12.5%,\n p<\/jats:italic>\n \u2009=\u2009.041) in the extramedullary tissues than in the paired bone marrow samples. At diagnosis, the percentage of\n MYC<\/jats:italic>\n translocations in the sEMD group was notably higher than that in the non\u2010EMD group (55.6% vs. 15.5%,\n p<\/jats:italic>\n \u2009=\u2009.012). The median overall survival (OS) of patients with pEMD\u2010S (32\u2009months) and sEMD (17\u2009months) was significantly shorter (both\n p<\/jats:italic>\n \u2009=\u2009.001) than that of non\u2010EMD patients (60\u2009months).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Soft\u2010tissue EMD can be considered a high\u2010risk condition, even in the era of novel agents.\n MYC<\/jats:italic>\n translocation can serve as a valuable marker that correlates with extramedullary spread and relapse in patients with MM and should be considered for inclusion in routine FISH panels in clinical practice.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ejh.14296","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T22:29:15Z","timestamp":1724797755000},"page":"824-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\n MYC<\/i>\n <\/scp>\n translocation is a valuable marker for the development and relapse of extramedullary disease in multiple myeloma"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-5311","authenticated-orcid":false,"given":"Yuhang","family":"Song","sequence":"first","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"},{"name":"Peking Union Medical College, Chinese Academy and Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"},{"name":"Peking Union Medical College, Chinese Academy and Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"},{"name":"Peking Union Medical College, Chinese Academy and Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congwei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaimi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daobin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-0551","authenticated-orcid":false,"given":"Junling","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Hematology Peking Union Medical College Hospital Beijing 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