{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:19:26Z","timestamp":1790864366585,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Recent front\u2010line clinical trials used the International Prognostic Index (IPI) to identify trial\u2010eligible patients with newly diagnosed diffuse large B\u2010cell lymphoma (DLBCL). However, many IPI\u2010like variants with improved accuracy have been developed over the years for rituximab\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the impact of International Prognostic Indices on patient enrolment in clinical trials, aiming to exclude low\u2010risk IPI patients based on POLARIX\/EPCORE DLBCL\u20102 trial criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 2877 patients in the Danish Lymphoma Registry who would have been eligible for the POLARIX trial if patients with IPI 0\u20131 scores were included. IPI and NCCN\u2010IPI assigned 33.3% and 11.9% of patients to the low\u2010risk group, respectively. Shorter 5\u2010year overall survival (91.4% vs. 97.5%), higher relapse rate (9.9% vs. 4.4%), and more deaths (16.1% vs. 4.4%) occurred in the low\u2010risk IPI group compared with low\u2010risk NCCN\u2010IPI group. Analyzed models failed to identify true high\u2010risk patients with poor prognosis. Similar results were found in the confirmatory cohort developed based on EPCORE DLBCL\u20102 trial eligibility criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>True low\u2010risk patients are more optimal identified by NCCN\u2010IPI and should be excluded from front\u2010line clinical trials due to their excellent prognosis. However, additional high\u2010risk factors besides clinical prognostic models need to be considered when selecting trial\u2010eligible patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14301","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T02:08:34Z","timestamp":1726020514000},"page":"26-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Real\u2010World Data\u2010Based Analysis of Prognostic Indices as Part of Trial Eligibility Criteria in Diffuse Large B\u2010Cell Lymphoma Patients"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-8539","authenticated-orcid":false,"given":"Jelena","family":"Jelicic","sequence":"first","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense 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