{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:54Z","timestamp":1787014134059,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In a randomized phase II trial (AMLSG 14\u201009, NCT00867672) of elderly, newly diagnosed AML patients, ATRA combined with decitabine (DEC) significantly improved the overall response rate (ORR) and survival also in patients with adverse\u2010risk genetics, without adding toxicity. We performed a post hoc analysis to determine the predictive impact of\n                    <jats:italic>TP53<\/jats:italic>\n                    status. Despite a nominally higher ORR, the clinically meaningful survival benefit when adding ATRA to DEC was diminished, but not completely negated, in\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated patients. Indeed, 2 out of 14\n                    <jats:italic>TP53<\/jats:italic>\n                    \u2010mutated patients (14%) randomized to a DEC\u2009+\u2009ATRA\u2010containing regimen lived for &gt;\u200936\u2009months. Further studies of ATRA combined with hypomethylating agents appear warranted in non\u2010M3 AML patients ineligible for HMA\/venetoclax therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT00867672\n                  <\/jats:p>","DOI":"10.1111\/ejh.14304","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T02:20:06Z","timestamp":1728872406000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of\n                    <i>TP53<\/i>\n                    Mutation Status in Elderly\n                    <scp>AML<\/scp>\n                    Patients When Adding All\u2010\n                    <i>Trans<\/i>\n                    Retinoic Acid or Valproic Acid to Decitabine"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3724-5982","authenticated-orcid":false,"given":"Helena","family":"Bresser","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University Medical Center Freiburg, Faculty of Medicine  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schmoor","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit University Medical Center Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Grishina","sequence":"additional","affiliation":[{"name":"Clinical Trials Unit University Medical Center Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Stem Cell Transplantation University 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