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Various regimens, for example, locoregional treatment and systemic chemo\u2010immunotherapy, can be used depending on the site and stage of disease. Single\u2010agent rituximab is a useful approach in the setting of localized, low\u2010intermediate risk EMZL. The aim our research was to analyze the effectiveness and safety of single\u2010agent rituximab (375\u2009mg\/m<jats:sup>2<\/jats:sup> once weekly for 4\u2009weeks) in na\u00efve EMZL in a real\u2010life setting. The primary endpoint was the overall response rate (ORR), secondary endpoints were progression\u2010free (PFS), overall (OS) and disease\u2010free survivals (DFS), and drug tolerability. Fifty\u2010nine patients were analyzed. Median time between diagnosis and rituximab was 3.6\u2009months. The ORR was 89.9%, with 67.8% complete response (CR). Median DFS and PFS were reached at 6.3 and 5.3\u2009years, respectively. After a median follow\u2010up of 5\u2009years, median OS was not reached. The most common adverse event was infusion reaction, reported in 28 cases, mainly during the first infusion and easily manageable. Single\u2010agent rituximab may represent a valid therapeutic option in the first\u2010line treatment of EMZL, at least for localized disease, with a favorable toxicity profile.<\/jats:p>","DOI":"10.1111\/ejh.14306","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T01:24:20Z","timestamp":1726709060000},"page":"70-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy and Safety of Frontline Single\u2010Agent Rituximab in Extranodal Marginal Zone Lymphoma"],"prefix":"10.1111","volume":"114","author":[{"given":"Camilla","family":"Mazzoni","sequence":"first","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Istituto di Ematologia \u201cSer\u00e0gnoli\u201d  Bologna Italy"},{"name":"Dipartimento di Scienze Mediche e Chirurgiche Universit\u00e0 di Bologna  Bologna 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