{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:28:45Z","timestamp":1791822525479,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005565","name":"Johnson & Johnson Innovative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005565","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Warm autoimmune hemolytic anemia (wAIHA) is a rare autoantibody\u2010mediated disorder, and first\u2010line treatment primarily relies on corticosteroids. This study assessed overall survival (OS) and treatment patterns of wAIHA in Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults with \u2265\u20091 primary diagnosis code for wAIHA (or AIHA plus oral corticosteroids (OCS)\/immunosuppressants as sensitivity analyses) between 2011 and 2022 were identified from five Swedish national registers and linked through each patient's unique identity number. Kaplan\u2013Meier curves with log\u2010rank tests and Cox regressions were performed to assess OS for patients with primary versus secondary wAIHA and patients with wAIHA and long\u2010term versus short\u2010term (\u2265\u20093 vs. &lt;\u20093\u2009months) OCS users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main analysis included 292 patients; 1791 patients were included in the sensitivity analysis. At a median 3.7\u2010year follow\u2010up, a median OS in primary wAIHA was not reached versus 6.0\u2009years for secondary wAIHA (log\u2010rank test: <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Subgroup analyses showed no significant difference in risk of death between long\u2010term and short\u2010term OCS users; however, in the sensitivity analysis, long\u2010term OCS users showed significantly higher risk of death (adjusted hazard ratio: 1.45; 95% confidence interval: 1.180, 1.781; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) versus short\u2010term OCS users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Secondary wAIHA or long\u2010term OCS use was associated with lower OS, underscoring the disease burden and unmet need for efficacious wAIHA treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14311","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T09:24:25Z","timestamp":1728465865000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Overall Survival and Treatment Patterns Among Patients With Warm Autoimmune Hemolytic Anemia in Sweden: A Nationwide Population\u2010based Study"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-4002","authenticated-orcid":false,"given":"Honar","family":"Cherif","sequence":"first","affiliation":[{"name":"Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cai","sequence":"additional","affiliation":[{"name":"Janssen Global Services, LLC, a Johnson &amp; Johnson Company  Raritan New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Crivera","sequence":"additional","affiliation":[{"name":"Janssen Global Services, LLC, a Johnson &amp; Johnson Company  Horsham Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Leon","sequence":"additional","affiliation":[{"name":"Janssen Global Services, LLC, a Johnson &amp; Johnson Company  Horsham Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iffat","family":"Rahman","sequence":"additional","affiliation":[{"name":"SDS Life Science\u2014A Cytel Company  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Leval","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica NV  Solna Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Noel","sequence":"additional","affiliation":[{"name":"Janssen Pharmaceutica NV  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kjellander","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Internal Medicine Capio St G\u00f6ran Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.690"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S250250"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123859"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1900554"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-69892-2_62-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00946"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.100648"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.14740\/jh303w"},{"key":"e_1_2_8_10_1","article-title":"Autoimmune Hemolytic Anemia Confers an Independent Risk Factor for Thrombosis: Retrospective Cohort Study Using the \u201cSTRIDE\u201d Database","volume":"4","author":"Chen E. 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