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Intercellular adhesion molecule 1 (ICAM\u20101) plays a crucial role in the pathophysiology of SCD by promoting the adhesion of sickle cells to the endothelium, contributing to vaso\u2010occlusion and tissue damage. The ICAM\u20101 gene encodes a glycoprotein that interacts with lymphocyte function\u2013associated antigen 1 (LFA\u20101) and macrophage 1\u2010antigen (Mac\u20101) receptors, perpetuating inflammation, and oxidative stress. The NF\u2010\u03baB signaling pathway regulates ICAM\u20101 expression, which is elevated in patients with SCD, leading to increased endothelial cell activation and damage. Targeting ICAM\u20101 and its interactions with sickle cells and the endothelium has emerged as a potential therapeutic strategy for managing SCD. This review highlights the complex interplay between ICAM\u20101, sickle cells, and the endothelium, and discusses the potential of ICAM\u20101\u2010targeted therapies for mitigating VOC and improving the quality of life for patients with SCD.<\/jats:p>","DOI":"10.1111\/ejh.14313","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T06:14:21Z","timestamp":1727849661000},"page":"730-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeting <scp>ICAM1<\/scp> to Ameliorate Vaso\u2010Occlusion and Inflammation in Sickle Cell Disease"],"prefix":"10.1111","volume":"113","author":[{"given":"Parul","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Genetic Disorders ICMR\u2010National Institute of Research in Tribal Health  Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Genetic Disorders ICMR\u2010National Institute of Research in Tribal Health  Jabalpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.11"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000491"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2005.08.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13430"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200452"},{"issue":"9","key":"e_1_2_10_7_1","first-page":"1322","article-title":"Disease Genotype, Haplotypes, Diagnosis and Associated Studies in Sickle Cell Anemia","volume":"149","author":"D\u00edaz\u2010Matallana M.","year":"2021","journal-title":"Revista M\u00e9dica de Chile"},{"key":"e_1_2_10_8_1","first-page":"267","article-title":"Hemoglobin Types and Hemoglobinopathies. 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