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In this Italian multicenter real\u2010life observational retrospective study, efficacy and safety of the Isa\u2010Kd regimen were evaluated in a cohort of 103 RRMM patients. Overall response rate (ORR) was 85%, with stringent (sCR) or complete response (CR) in 18% of cases and very good partial response (VGPR) in 39%. Median PFS and OS were not reached within the study period, while 1\u2010year PFS and OS were 72% and 77%, respectively. Hematological toxicities were observed in 42% of subjects, and cardiac toxicities occurred in 24% of cases. Moreover, we conducted a subanalysis on patients (<jats:italic>N<\/jats:italic>\u2009=\u200969) treated with Isa\u2010Kd after one prior line of therapy, showing an ORR of 88%, with sCR\u2009+\u2009CR in 20% of subjects, VGPR in 46%, and PR in 22% of patients. In this group, median PFS and OS were not reached, while 1\u2010year PFS and OS were 92% and 95%, respectively. In conclusions, our study confirmed Isa\u2010Kd as an effective treatment option for RRMM with a manageable safety profile even in real\u2010life settings.<\/jats:p>","DOI":"10.1111\/ejh.14314","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T21:29:48Z","timestamp":1728250188000},"page":"105-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Efficacy of Isatuximab Plus Carfilzomib and Dexamethasone in Relapsed\/Refractory Multiple Myeloma Patients"],"prefix":"10.1111","volume":"114","author":[{"given":"Danilo","family":"De Novellis","sequence":"first","affiliation":[{"name":"Hematology and Transplant Center University Hospital \"San Giovanni di Dio e Ruggi d'Aragona\"  Salerno Italy"},{"name":"Department of Medicine, Surgery and Dentistry \"Scuola Medica Salernitana\" University of Salerno  Baronissi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Derudas","sequence":"additional","affiliation":[{"name":"S.C. di Ematologia e C.T.M.O. 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