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Fifteen patients (median age 60\u2009years) with PTL (<jats:italic>n<\/jats:italic>\u2009=\u20095) or DLBCL\u2010T (<jats:italic>n<\/jats:italic>\u2009=\u200910) received high\u2010dose methotrexate\u2009+\u2009R\u2010CHOP. Overall, complete response (CR) rate was 73% and overall response rate 86%. With a 3.9\u2010year median follow\u2010up, 100% of patients with PTL had CR and none relapsed. On the contrary, 55% of DLBCL\u2010T patients achieved CR among which only one was still in remission at the end of follow\u2010up. Molecular parallels between PTL and Primary CNS Lymphoma (PCNSL) suggest shared origins, urging further research for tailored treatments and enhanced understanding of these lymphomas' biology.<\/jats:p>","DOI":"10.1111\/ejh.14325","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T08:05:02Z","timestamp":1728720302000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biological Findings and Clinical Outcomes in Patients Treated With R\u2010<scp>CHOP<\/scp> Plus High\u2010Dose Methotrexate as First\u2010Line Therapy in Large B\u2010Cell Lymphoma With Testis Involvement"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-591X","authenticated-orcid":false,"given":"R.","family":"Li\u00e9vin","sequence":"first","affiliation":[{"name":"Clinical Hematology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"},{"name":"Laboratory of Molecular Mechanisms of Hematological Disorders and Therapeutic Implications INSERM U 1163, Institut Imagine  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Burroni","sequence":"additional","affiliation":[{"name":"Pathology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Balducci","sequence":"additional","affiliation":[{"name":"Cytogenetics Department AP\u2010HP, H\u00f4pital Necker\u2010Enfants Malades, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Palmic","sequence":"additional","affiliation":[{"name":"Pathology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Decroocq","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Deau\u2010Fischer","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Franchi","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vignon","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department AP\u2010HP, H\u00f4pital Cochin, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Zerbit","sequence":"additional","affiliation":[{"name":"Pharmacy Department AP\u2010HP, Hospitalisation \u00e0 Domicile APHP, Universit\u00e9 de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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