{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:27:25Z","timestamp":1792466845865,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The introduction of tyrosine kinase inhibitors has considerably improved the life expectancy (LE) for patients with chronic myeloid leukemia (CML). Evaluating health\u2010related quality of life within the treatment pathway remains crucial. Using the Swedish CML register, we included 991 adult patients with chronic\u2010phase (CP) CML diagnosed 2007 to 2017, with follow\u2010up until 2018. We developed a multistate model to estimate the loss in LE (LLE) and loss in quality\u2010adjusted life expectancy (LQALE) for the patient population compared to the general population, along with the respective proportions of losses relative to the general population. All patients with CP\u2010CML had a relatively low reduced LE but with larger LQALE. The maximum LLE within age\/sex subgroups was 5.7\u2009years (general population LE: 43.2\u2009years vs. CP\u2010CML LE: 37.5\u2009years) for females diagnosed at age 45\u2009years, with LQALE of 12.0 quality\u2010adjusted life years (QALYs) (general population QALE: 38.2 QALYs vs. CP\u2010CML QALE: 26.3 QALYs). Across all ages, the proportions of LLE ranged from 9% to 15%, and the proportions of LQALE were 29% to 33%. Despite a low LLE, our findings reveal a greater LQALE for patients with CP\u2010CML. Further improvements in management of CP\u2010CML are thus warranted to successfully address the prevailing medical needs.<\/jats:p>","DOI":"10.1111\/ejh.14328","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T03:03:55Z","timestamp":1730862235000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Loss in Overall and Quality\u2010Adjusted Life Expectancy for Patients With Chronic\u2010Phase Chronic Myeloid Leukemia"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-708X","authenticated-orcid":false,"given":"Enoch Yi\u2010Tung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-7227","authenticated-orcid":false,"given":"Torsten","family":"Dahl\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna, Clinical Epidemiology Division Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital Solna  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Stenke","sequence":"additional","affiliation":[{"name":"Department of Hematology Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bj\u00f6rkholm","sequence":"additional","affiliation":[{"name":"Department of Hematology Karolinska University Hospital Solna  Stockholm Sweden"},{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Dickman","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Clements","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","volume-title":"Hoffbrand's Essential Haematology","author":"Hoffbrand A. 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