{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:18:00Z","timestamp":1787509080927,"version":"build-2736575974"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Voxelotor modifies hemoglobin\u2010oxygen affinity improving anemia and reducing hemolysis in sickle cell patients. However, the impact of Voxelotor on fetal hemoglobin (HbF)\u00a0levels is unknown. We describe here variations of percentage of HbF measured by high performance liquid chromatography and mean corpuscular fetal Hb in a cohort of sickle cell patients treated with Voxelotor at Henri Mondor Sickle Cell Referral Center. Our data show a decrease in HbF levels in sickle cell patients after 6\u2009months of treatment with Voxelotor, which is likely to be associated with an increase in the lifespan of red blood cells that are no longer prematurely removed from the circulation, particularly those with low HbF. This work raises the question of the risk of a rebound effect when stopping Voxelotor, which has a short half\u2010life, during the time it takes to increase HbF.<\/jats:p>","DOI":"10.1111\/ejh.14332","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T03:19:19Z","timestamp":1729480759000},"page":"264-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fetal Hemoglobin Decrease During Voxelotor Treatment"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4138-4218","authenticated-orcid":false,"given":"Gonzalo","family":"De Luna","sequence":"first","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoosha","family":"Habibi","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Moutereau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biochimie\u2010Biologie Mol\u00e9culaire\u2010Pharmacologie\u2010G\u00e9n\u00e9tique M\u00e9dicale Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suella","family":"Martino","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila","family":"Alhamrouni","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Pharmacology, Centre of Pharmacovigilance Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9978-0622","authenticated-orcid":false,"given":"Yanis","family":"Pelinski","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosr","family":"Zaouali","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Bartolucci","sequence":"additional","affiliation":[{"name":"Sickle Cell Referral Center, Department of Internal Medicine Henri\u2010Mondor University Hospital\u2010 UPEC  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris\u2010Est Cr\u00e9teil, INSERM, IMRB, Laboratory of Excellence LABEX GRex  Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00118-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903212"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"320","article-title":"Cons\u00e9quences du traitement par voxelotor sur les profils \u00e9lectrophor\u00e9tiques et chromatographiques de l'h\u00e9moglobine [Impact of voxelotor on hemoglobin electrophoretic and chromatographic profiles]","volume":"81","author":"Fellahi S.","year":"2023","journal-title":"Annales de Biologie clinique (Paris)"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-008318"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-591453"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ejh.14332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T08:52:56Z","timestamp":1737449576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ejh.14332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/ejh.14332"],"URL":"https:\/\/doi.org\/10.1111\/ejh.14332","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,21]]},"assertion":[{"value":"2024-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}