{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:05:32Z","timestamp":1785891932351,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1R21ES034226\u201001"],"award-info":[{"award-number":["1R21ES034226\u201001"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["7R01DA049657"],"award-info":[{"award-number":["7R01DA049657"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016325","name":"Children's of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["U54MD000502"],"award-info":[{"award-number":["U54MD000502"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute Chest Syndrome (ACS) is the leading cause of death in children with sickle cell disease (SCD) in the US\u2014about half of the children who develop ACS present initially with pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here, we studied biomarkers to differentiate ACS from vaso\u2010occlusive crises (VOC) in children with SCD who presented with pain to the emergency department (ED). We conducted a prospective cohort study of consecutive patients who presented to the ED with pain and were discharged with ACS or VOC between March, 2017 and February, 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 7 patients with ACS and 19 patients with VOC. The two groups were comparable in age and sex. All patients with ACS had asthma versus 42% of the VOC group. The ACS group had lower weight and BMI z\u2010scores. Patients with ACS compared to VOC had significantly higher respiratory rates, lower O<jats:sub>2<\/jats:sub> saturation, and longer hospital stays. They also had higher white blood cell count, glucose level (&gt;\u200999\u2009mg\/dL), anion gap (&gt;\u20099\u2009mEq\/L), sPLA2 (&gt;\u20097\u2009pg\/mL), IFN\u2010\u03b3 (&gt;\u200917.8\u2009pg\/mL), IL\u201010 (1.54\u2009pg\/mL), and IL\u201012 (&gt;\u20090.5\u2009pg\/mL) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We identified biomarkers associated with ACS development in children with SCD presenting with pain that allow for earlier ACS interventions to reduce mortality and morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14342","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T10:20:14Z","timestamp":1730802014000},"page":"325-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biomarkers to Differentiate Acute Chest Syndrome From Vaso\u2010Occlusive Crisis in Children With Sickle Cell Disease"],"prefix":"10.1111","volume":"114","author":[{"given":"Karen","family":"Wang","sequence":"first","affiliation":[{"name":"Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelida","family":"Olave","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010Yeun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Heersink School of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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