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This retrospective study evaluated thrombotic and bleeding outcomes in adults treated for HIT\/HITT with a direct oral anticoagulant (DOAC) or warfarin between 2012 and 2023 within the Ochsner Health System. Patients with mechanical heart valves, valvular atrial fibrillation, antiphospholipid syndrome, active malignancy, or venous thromboembolism (VTE) within the previous 6\u2009months were excluded. The primary outcome was a composite of new or progressive VTE or arterial thromboembolism. Secondary outcomes included major and clinically relevant non\u2010major bleeding, duration of hospitalization, time to platelet recovery, and incidence of skin necrosis, gangrene, and amputation. Forty\u2010nine patients receiving a DOAC and 30 patients receiving warfarin were included. Baseline characteristics were similar between cohorts. There were non\u2010statistically significant increased rates of both the primary outcome (8.9% vs. 4.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.65) and the composite bleeding outcome (32.7% vs. 23.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.37) in the DOAC cohort. Larger, prospective studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1111\/ejh.14350","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:55:22Z","timestamp":1731585322000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Direct Oral Anticoagulants Versus Warfarin in Patients With Isolated Heparin\u2010Induced Thrombocytopenia or Heparin\u2010Induced Thrombocytopenia With Thrombosis"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3631-711X","authenticated-orcid":false,"given":"Kaiya","family":"Hassan","sequence":"first","affiliation":[{"name":"Ochsner Medical Center  New Orleans USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kinan","sequence":"additional","affiliation":[{"name":"Ochsner Medical Center  New Orleans 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