{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:53Z","timestamp":1787014133933,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Secondary malignancies are potential complications after high\u2010dose therapy and autologous stem cell transplantation (ASCT). Information on the detailed course of such events is scarce, yet may be essential to minimize the impact of these sequelae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We regularly monitored 877 patients for up to 31\u2009years after ASCT in our outpatient department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four\u2010hundred and five patients with malignant lymphoma and 472 patients with multiple myeloma were analysed with a median follow\u2010up from the initial malignant diagnosis of 7.0\u2009years (0.5\u201335.5), from ASCT of 4.8\u2009years (range 0.2\u201331.3). Eighty\u2010nine of these patients suffered from 94 invasive secondary malignancies (30 haematologic malignancies, 64 solid tumours). In 29 patients a non\u2010melanoma skin cancer was observed. 31\/64 (48%) patients with solid tumours were diagnosed in an early stage of the disease (UICC 0\u20132) and had a chance of cure. 5% of the patients developed an invasive malignancy within 5\u2009years, 12% within 10\u2009years, 21% within 20\u2009years. Risk factors were advanced age, the diagnosis lymphoma and in lymphoma patients additionally male sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Secondary malignancies after ASCT are relatively frequent complications. Our findings suggest that systematic life\u2010long cancer screening after ASCT is essential to improve the prognosis of these adverse events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14355","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T07:18:59Z","timestamp":1733815139000},"page":"536-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secondary Malignancies After Autologous Stem Cell Transplantations in Patients With Malignant Lymphoma and Multiple Myeloma"],"prefix":"10.1111","volume":"114","author":[{"given":"Bernd","family":"Metzner","sequence":"first","affiliation":[{"name":"Department of Oncology and Haematology, Klinikum Oldenburg University Clinic  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Red Cross Blood Transfusion 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-5024","authenticated-orcid":false,"given":"Andreas","family":"Vo\u00df","sequence":"additional","affiliation":[{"name":"Department of Oncology and Haematology, Klinikum Oldenburg University Clinic  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Henning","family":"K\u00f6hne","sequence":"additional","affiliation":[{"name":"Department of Oncology and Haematology, Klinikum Oldenburg University Clinic  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01227-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.galenos.2023.2022-10-56"},{"key":"e_1_2_11_4_1","first-page":"1","article-title":"Long\u2010Term Effectiveness and Safety of 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