{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:47:41Z","timestamp":1791330461775,"version":"4.3.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This final post hoc analysis evaluated patient\u2010reported outcomes from the Phase 3 MAIA study of daratumumab, lenalidomide, and dexamethasone (D\u2010Rd) versus lenalidomide and dexamethasone (Rd) after median 64.5\u2010month follow\u2010up in transplant\u2010ineligible patients with newly diagnosed multiple myeloma (NDMM), including patient subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Key scales from the EORTC QLQ\u2010C30 (global health status [GHS], physical functioning, pain, and fatigue) were assessed. Scores were evaluated every 3\u2009months for 1\u2009year, then every 6\u2009months until disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The intent\u2010to\u2010treat population (<jats:italic>n<\/jats:italic>\u2009=\u2009737) included 46.3% frail, 35.4% 70 to &lt;\u200975\u2009years old, and 43.6% \u2265\u200975\u2009years old. D\u2010Rd\u2010treated patients showed improvements from baseline that were sustained over 5\u2009years in the intent\u2010to\u2010treat population and across subgroups by age, frailty, and bone lesions. Greater proportions of patients treated with D\u2010Rd versus Rd achieved minimally important changes for improvement at cycle 36 (year ~3) in GHS (odds ratio, 1.84 [95% CI, 1.16\u20132.91]), physical functioning (1.93 [1.18\u20133.14]), pain (1.41 [0.90\u20132.22]), and fatigue (2.00 [1.24\u20133.23]). Greater proportions of patients with bone lesions improved with D\u2010Rd versus Rd on GHS and physical functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In transplant\u2010ineligible patients with NDMM, D\u2010Rd improved health\u2010related quality of life over a 5\u2010year period versus Rd.<\/jats:p><jats:p>\n<jats:bold>Trial Registration:<\/jats:bold> <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT02252172<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14392","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T22:28:39Z","timestamp":1739572119000},"page":"883-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Sustained Improvement in Health\u2010Related Quality of Life in Transplant\u2010Ineligible Newly Diagnosed Multiple Myeloma Treated With Daratumumab, Lenalidomide, and Dexamethasone: <scp>MAIA<\/scp> Final Analysis of Patient\u2010Reported Outcomes"],"prefix":"10.1111","volume":"114","author":[{"given":"Aurore","family":"Perrot","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire de Toulouse Service d'H\u00e9matologie  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Facon","sequence":"additional","affiliation":[{"name":"University of Lille, CHU Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Plesner","sequence":"additional","affiliation":[{"name":"Vejle Hospital and University of Southern Denmark  Vejle Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad Z.","family":"Usmani","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaji","family":"Kumar","sequence":"additional","affiliation":[{"name":"Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar J.","family":"Bahlis","sequence":"additional","affiliation":[{"name":"University of Calgary, Arnie Charbonneau Cancer Research Institute  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Hulin","sequence":"additional","affiliation":[{"name":"H\u00f4pital Haut Leveque University Hospital  Pessac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Z.","family":"Orlowski","sequence":"additional","affiliation":[{"name":"The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-5094","authenticated-orcid":false,"given":"Hareth","family":"Nahi","sequence":"additional","affiliation":[{"name":"Karolinska University Hospital at Huddinge  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mollee","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital and University of Queensland Medical School  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthik","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals, NHS Foundation Trust  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-9428","authenticated-orcid":false,"given":"Murielle","family":"Roussel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jaccard","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire  Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Delforge","sequence":"additional","affiliation":[{"name":"University Hospital Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Karlin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon Sud  Pierre\u2013B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7719-3611","authenticated-orcid":false,"given":"Bertrand","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Immuno\u2010H\u00e9matologie Hospital Saint Louis, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajai","family":"Chari","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Wang","sequence":"additional","affiliation":[{"name":"Johnson &amp; 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