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Clinical manifestations of eosinophilia\u2010related disorders range from mild to life\u2010threatening. Given the various symptoms, a comprehensive approach and close multidisciplinary cooperation are strongly recommended. Hypereosinophilic syndromes (HES) encompass a complex group of disorders defined as persistent peripheral blood HE \u2265\u20091500\/mm<jats:sup>3<\/jats:sup> and end\u2010organ damage. An initial step in a diagnostic algorithm of HE includes the evaluation of secondary, potentially easy\u2010to\u2010treat causes. This HES variant is called reactive and often remains beyond the interest of hematologists. The further evaluation for primary causes of HE relies on a combination of different specialized tests, which are mostly available in hematologic centers and include most of all morphologic assessments of peripheral blood and bone marrow, cytogenetics, and molecular studies. Using these sophisticated methods, one can diagnose the specific HES subtypes based on genetic findings and categorize them according to currently applicable classifications. The choice of therapy differs between HES variants, ranging from corticosteroids and anti\u2010interleukin\u20105 monoclonal antibodies for not\u2010molecularly defined variants to oral molecules directed against molecular targets. This review presents eosinophilia\u2010related disorders from a hematologic perspective.<\/jats:p>","DOI":"10.1111\/ejh.14396","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T20:19:21Z","timestamp":1739823561000},"page":"763-774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Management of Persistent Hypereosinophilia"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-1268","authenticated-orcid":false,"given":"Grzegorz","family":"Helbig","sequence":"first","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Faculty of Medicine in Katowice, Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacper","family":"Czachor","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Faculty of Medicine in Katowice, Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ai.2018.03.001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0150-2021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236107"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.01.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.95"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012419-032756"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.019"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15544"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-11-551614"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.022"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.16463"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.035"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27287"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.10.2759.2759"},{"key":"e_1_2_13_16_1","first-page":"253","article-title":"Prognostic Factors of Hypereosinophilic Syndrome. 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