{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:21:25Z","timestamp":1789676485689,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32 CA203703"],"award-info":[{"award-number":["T32 CA203703"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Myeloma cast nephropathy (MCN) is a driver of renal failure in newly diagnosed multiple myeloma (NDMM) and has been historically associated with increased early mortality. Since patients with moderate to severe renal insufficiency are typically excluded from trials, we performed a retrospective study to characterize modern\u2010era outcomes in MCN. We reviewed 274 consecutive NDMM patients from 2017 to 2023 at an academic center and identified 46 patients (16.8%) with MCN. Among them, 96% had received bortezomib and 67% anti\u2010CD38<jats:sup>+<\/jats:sup> monoclonal antibody in frontline therapy. As per the International Myeloma Working Group criteria, the renal overall response rate was 76.1% (35\/46), and the renal complete response (CR) rate was 32.6% (15\/46) at 6\u2009months. Overall survival (OS) at 6\u2009months did not differ between MCN (100%) and controls (98.2%). At a median follow\u2010up of ~3\u2009years, the mean MCN OS was within 7\u2009months of control (<jats:italic>p<\/jats:italic>\u2009=\u20090.039) by equivalence testing. Most involved free light chain (iFLC) and proteinuria reduction occurred within 1\u2009month of treatment (83.1%, 3.9\u2009g\/d, respectively). In summary, we report excellent 6\u2010month renal recovery without early mortality in MCN patients with modern anti\u2010myeloma therapies. Prospective studies focused on MCN are urgently needed to further improve the renal CR rate.<\/jats:p>","DOI":"10.1111\/ejh.14403","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T20:55:41Z","timestamp":1741726541000},"page":"990-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Improved Outcomes of Myeloma Cast Nephropathy in Newly Diagnosed Multiple Myeloma With Modern Anti\u2010Myeloma Therapies"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8042-5006","authenticated-orcid":false,"given":"Michael Sang","family":"Hughes","sequence":"first","affiliation":[{"name":"Department of Hematology\/Oncology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metodi","family":"Balev","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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