{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:49:29Z","timestamp":1787964569188,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021954","name":"Tour de Cure","doi-asserted-by":"publisher","award":["RSP\u2010117\u2010FY2023"],"award-info":[{"award-number":["RSP\u2010117\u2010FY2023"]}],"id":[{"id":"10.13039\/501100021954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Patient\u2010reported outcomes (PROs), including physical function, have predictive potential for survival but remain underexplored in multiple myeloma (MM). This study evaluates the predictive and prognostic value of PROs for treatment outcomes in MM patients on daratumumab\u2010based therapy and evaluates physical function versus ECOG Performance Status as a potential treatment\u2010effect modifier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data was pooled from randomized trials (MAIA, POLLUX, CASTOR) that collected pretreatment PROs using EORTC QLQ\u2010C30. Cox models and logistic regression examined associations between PROs and overall survival (OS), progression\u2010free survival (PFS) and grade \u2265\u20093 adverse events. Physical function versus ECOG\u2010PS was examined as a treatment effect modifier for daratumumab versus non\u2010daratumumab therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1804 patients, 1535 (85%) had pretreatment PROs. Physical function, global health, and fatigue were most prognostic for survival and adverse events. Physical function provided independent prognostic value beyond ECOG\u2010PS and was predictive of treatment effect. Low physical function patients experienced greater OS treatment benefit (adjusted HR (aHR) [95% CI] 0.53 [0.40\u20130.70], <jats:italic>p<\/jats:italic> interaction\u2009=\u20090.02) and PFS (aHR [95% CI] 0.30 [0.30\u20130.48], <jats:italic>p<\/jats:italic> interaction\u2009=\u20090.03) from daratumumab versus high\u2010physical function (OS aHR 0.86 [0.62\u20131.19], PFS aHR 0.53 [0.42\u20130.67]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Physical function is a predictive and prognostic marker that complements ECOG\u2010PS, supporting its use in informing therapy decisions for daratumumab\u2010based treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14410","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T09:45:32Z","timestamp":1741945532000},"page":"1020-1031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictive and Prognostic Significance of Patient\u2010Reported Outcomes for Survival and Adverse Events in Daratumumab\u2010Treated Multiple Myeloma"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4182-065X","authenticated-orcid":false,"given":"Ahmad Y.","family":"Abuhelwa","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice and Pharmacotherapeutics University of Sharjah  Sharjah UAE"},{"name":"Research Institute of Medical and Health Sciences University of Sharjah  Sharjah UAE"},{"name":"College of Medicine and Public Health Flinders University  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Almansour","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Pharmacotherapeutics University of Sharjah  Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Basch","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaid O.","family":"Al\u2010Shamsi","sequence":"additional","affiliation":[{"name":"Department of Oncology Burjeel Cancer Institute  Abu Dhabi UAE"},{"name":"Emirates Oncology Society  Dubai UAE"},{"name":"College of Medicine, Ras Al Khaimah Medical and Health Sciences  Ras Al Khaimah UAE"},{"name":"Gulf Cancer Society  Alsafa Kuwait"},{"name":"College of Medicine University of Sharjah  Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Abuhelwa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology University of South Florida\/H. Lee Moffitt Cancer Center and Research Institute  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Bustanji","sequence":"additional","affiliation":[{"name":"College of Medicine University of Sharjah  Sharjah UAE"},{"name":"School of Pharmacy The University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Semreen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Pharmacotherapeutics University of Sharjah  Sharjah UAE"},{"name":"Department of Medicinal Chemistry University of Sharjah  Sharjah UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelal","family":"Kharaba","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Pharmacotherapeutics University of Sharjah  Sharjah UAE"},{"name":"Research Institute of Medical and Health Sciences University of Sharjah  Sharjah 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