{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T04:15:56Z","timestamp":1746591356892,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on bone marrow (BM) findings in secondary hemophagocytic lymphohistiocytosis (sHLH) and their association with overall survival (OS) are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to develop a prognostic model incorporating BM findings and clinico\u2010laboratory factors affecting OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated 50 adults with sHLH and developed a clinicopathological prognostic model based on survival\u2010associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients demonstrated normocellular BM (46.3%) and mild hemophagocytic activity (44.2%). Factors associated with survival in multivariable analyses (MVA) were age above 70\u2009years (hazard ratio [HR] 3.89, <jats:italic>p<\/jats:italic>\u2009=\u20090.016), infection\u2010related (HR 4.62, <jats:italic>p<\/jats:italic>\u2009=\u20090.006), hemoglobin &lt;\u20097\u2009g\/dL (HR 5.21, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and hypocellular marrow (HR 3.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). A clinicopathological HLH risk model assigned 1 point to each MVA\u2010identified survival factor, categorizing patients into low\u2010 (score 0\u20131), intermediate\u2010 (score 2\u20133), and high\u2010risk (score 4) groups. The 6\u2010month OS from bootstrapping internal validation among the low\u2010, intermediate\u2010, and high\u2010risk groups were 84.2%, 55.6% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and 7.7% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), respectively. The area under the receiver operating characteristic curve (AuROC) was 0.87.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This model stratified sHLH patients into three risk groups with distinct survival outcomes, potentially guiding future therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14412","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:51:58Z","timestamp":1742039518000},"page":"1032-1040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological Prognostic Model for Survival in Adult Patients With Secondary Hemophagocytic Lymphohistiocytosis"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-5564","authenticated-orcid":false,"given":"Pongthep","family":"Vittayawacharin","sequence":"first","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"},{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1678-1345","authenticated-orcid":false,"given":"Benjamin J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of California Irvine Health  Orange California USA"},{"name":"Department of Clinical Pharmacy Practice School of Pharmacy &amp; Pharmaceutical Sciences, University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghayda'","family":"E'leimat","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine University of California Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Gamayo","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif","family":"Rezk","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Irvine  Irvine California 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