{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:44:13Z","timestamp":1776689053739,"version":"3.51.2"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Relapsed\/refractory multiple myeloma (RRMM) research on the impact of +1q abnormalities in real\u2010world settings is limited. This study evaluated the prognostic and predictive significance of 1q gain [gain(1q)] and amplification [ampl(1q)] in 635 RRMM patients treated with daratumumab\u2010, elotuzumab\u2010, and carfilzomib\u2010based triplet regimens. Patients with +1q abnormalities had lower deep response rates [\u2265\u2009CR: 9.4% for gain(1q), 11.6% for ampl(1q)] versus 20.2% in +1q\u2010negative patients. Multivariable ordinal logistic analysis showed significantly lower odds of achieving \u2265\u2009CR in patients with gain(1q) (OR\u2009=\u20090.49, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) or ampl(1q) (OR\u2009=\u20090.58, <jats:italic>p<\/jats:italic>\u2009=\u20090.0037). Progression\u2010free survival (PFS) was longer in +1q\u2010negative patients (28\u2009months) compared to those with gain(1q) (8\u2009months) or ampl(1q) (7.4\u2009months). Multivariable models identified gain(1q) (HR\u2009=\u20091.9, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and ampl(1q) (HR\u2009=\u20092.2, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as independent negative prognostic factors alongside del17p, <jats:italic>t<\/jats:italic>(4;14), creatinine clearance &lt;\u200960\u2009mL\/min, and ISS Stages II and III. Similarly, overall survival (OS) was reduced for patients with gain(1q) (25\u2009months) and ampl(1q) (19.5\u2009months) versus 42.2\u2009months in +1q\u2010negative patients. Multivariable analysis showed gain(1q) (HR\u2009=\u20091.6, <jats:italic>p<\/jats:italic>\u2009=\u20090.007) and ampl(1q) (HR\u2009=\u20092.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) as independent predictors of increased mortality. Ancillary +1q abnormalities associated with high\u2010risk cytogenetic changes were linked to both shorter PFS and OS. Stratification into no\u2010hit, single\u2010hit, double\u2010hit, and triple\u2010hit groups showed significant survival differences, emphasizing the impact of cumulative cytogenetic abnormalities on outcomes. In conclusion, +1q abnormalities significantly impact prognosis in RRMM and should be considered in risk stratification. The study emphasizes the importance of comprehensive cytogenetic profiling in real\u2010world settings and highlights the need for personalized treatment strategies to improve patient outcomes.<\/jats:p>","DOI":"10.1111\/ejh.14413","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:18:11Z","timestamp":1742357891000},"page":"16-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Significance of +1q Alterations in Relapsed\/Refractory Multiple Myeloma Treated With Daratumumab\u2010, Elotuzumab\u2010, and Carfilzomib\u2010Based Triplet Regimens: A Multicenter Real\u2010World Analysis of 635 Patients"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-7073","authenticated-orcid":false,"given":"Fortunato","family":"Morabito","sequence":"first","affiliation":[{"name":"Gruppo Amici Dell'Ematologia Foundation\u2010GrADE  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrica Antonia","family":"Martino","sequence":"additional","affiliation":[{"name":"Hematology Unit AO of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Galli","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplant Unit ASST Papa Giovanni XXIII  Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-7347","authenticated-orcid":false,"given":"Massimo","family":"Offidani","sequence":"additional","affiliation":[{"name":"Hematology Unit  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Zambello","sequence":"additional","affiliation":[{"name":"Department of Medicine (DIMED), Hematology and Clinical Immunology Padua University School of Medicine  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Bringhen","sequence":"additional","affiliation":[{"name":"Division of Hematology, AOU Citt\u00e0 Della Salute e Della Scienza di Torino University of Torino  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Hematology Unit Parma University Hospital  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catello","family":"Califano","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Unit \u201cA. 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