{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:47:43Z","timestamp":1791380863822,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The clinicopathologic and prognostic features of somatic <jats:italic>NF1<\/jats:italic> mutations have been well studied in pediatric myeloid neoplasms and adult acute myeloid leukemia (AML) but not in adult chronic myeloid neoplasms (CMNs), including myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), and myelodysplastic\/myeloproliferative neoplasms (MDS\/MPNs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed to identify adult patients diagnosed with <jats:italic>NF1<\/jats:italic>\u2010mutated CMNs between 1\/2010 and 8\/2023. Patients with <jats:italic>NF1<\/jats:italic> wildtype (<jats:italic>NF1<\/jats:italic>\u2010WT) CMNs concurrently diagnosed during the same time were used as a comparative group. Clinicopathologic and genetic characteristics and overall survival (OS) were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 36 <jats:italic>NF1\u2010<\/jats:italic>mutated CMNs were identified (4.7% of all CMNs), including 19 MDS, 4 MPNs, and 13 MDS\/MPNs (all CMML). <jats:italic>NF1<\/jats:italic>\u2010mutated CMMLs showed significantly higher absolute monocyte counts (AMC), more frequent complex karyotypes, and higher frequencies of <jats:italic>SRSF2<\/jats:italic> and <jats:italic>KRAS<\/jats:italic> mutations compared to <jats:italic>NF1<\/jats:italic>\u2010WT CMMLs. <jats:italic>NF1<\/jats:italic>\u2010mutated MDS also showed significantly higher AMC, lower frequency of <jats:italic>SF3B1<\/jats:italic>, and higher frequencies of <jats:italic>SRSF2<\/jats:italic> and <jats:italic>KRAS<\/jats:italic> mutations compared to <jats:italic>NF1<\/jats:italic>\u2010WT MDS. The OS of <jats:italic>NF1<\/jats:italic>\u2010mutated CMNs was significantly inferior to <jats:italic>NF1<\/jats:italic>\u2010WT CMNs (median survival: 2.05 vs. 4.8\u2009years; log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adult CMNs with mutated <jats:italic>NF1<\/jats:italic> show higher AMC, high\u2010risk molecular cytogenetic features, and inferior survival. Therefore, testing for <jats:italic>NF1<\/jats:italic> mutations could be considered part of risk assessment for patients with CMNs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14419","type":"journal-article","created":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T15:52:51Z","timestamp":1743349971000},"page":"46-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinicopathologic Characteristics and Prognostic Profile of Chronic Myeloid Neoplasms With Somatic <scp><i>NF1<\/i><\/scp> Mutations in Adult Patients"],"prefix":"10.1111","volume":"115","author":[{"given":"Hamza","family":"Tariq","sequence":"first","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Loxas","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir B.","family":"Alikhan","sequence":"additional","affiliation":[{"name":"Department of Pathology Endeavor Health  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juehua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Altman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine Robert H. 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