{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:29:10Z","timestamp":1790890150694,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012112","name":"Swedish Orphan Biovitrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012112","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report data from an ITI chart review study (NCT03951103) for first\u2010time and rescue ITI with recombinant factor VIII Fc fusion protein (rFVIIIFc) in persons with haemophilia A.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective and prospective real\u2010world data are reported from a non\u2010interventional, multicentre study of patients who had been or were currently being treated with rFVIIIFc ITI. ITI treatment outcome (defined by investigators) and regimens are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010one patients from 16 sites were included. First\u2010time ITI was used in 24 patients; 16 had an ITI outcome at study end. Thirteen patients (81.3%) had ITI success, and three had failure. Median (range) rFVIIIFc consumption was 300 (61\u20132800) IU\/kg\/week, and most (70.8%) used \u2264\u2009300\u2009IU\/kg\/week. The vast majority of patients (87.5%) received less than daily ITI.<\/jats:p>\n                    <jats:p>Rescue ITI was used in 17 patients; 16 had an ITI outcome at study end. Eight patients (50.0%) had ITI success\/partial success, seven had failure, and one withdrew early. Median (range) rFVIIIFc consumption was 536 (98\u20131435) IU\/kg\/week; 35.3% used \u2264\u2009300\u2009IU\/kg\/week and 52.9% used &gt;\u2009500\u2009IU\/kg\/week. Most patients (64.7%) received daily ITI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ITI with rFVIIIFc is likely to be successful in first\u2010time ITI patients and is an effective option for those who have previously experienced ITI failure.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT03951103\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ejh.14427","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:18:22Z","timestamp":1745799502000},"page":"134-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immune Tolerance Induction With a Recombinant Factor\n                    <scp>VIII<\/scp>\n                    Fc in Haemophilia A: Data From a Chart Review Study"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-8183","authenticated-orcid":false,"given":"Robert","family":"Klamroth","sequence":"first","affiliation":[{"name":"Vivantes Klinikum Friedrichshain  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3207-5698","authenticated-orcid":false,"given":"Mahasen","family":"Al Saleh","sequence":"additional","affiliation":[{"name":"King Faisal Specialist Hospital and Research Centre  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1153-4131","authenticated-orcid":false,"given":"Heidi","family":"Glosli","sequence":"additional","affiliation":[{"name":"Centre for Rare Disorders, Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-7795","authenticated-orcid":false,"given":"Michele","family":"Schiavulli","sequence":"additional","affiliation":[{"name":"Haemophilia and Congenital Bleeding Disorders, Treatment Center Santobono\u2010Pausilipon Children Hospital, AORN  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-8013","authenticated-orcid":false,"given":"Beno\u00eet","family":"Guillet","sequence":"additional","affiliation":[{"name":"Centre for Bleeding Disorders, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, 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