{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:07:13Z","timestamp":1787828833068,"version":"build-2784847793"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Myelodysplastic\/myeloproliferative overlap neoplasms (MDS\/MPN) are rare hematological malignancies. We analyzed the outcomes of 75 patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) for MDS\/MPN. Graft\u2010versus\u2010host disease (GvHD) prophylaxis included post\u2010transplantation cyclophosphamide (PTCy) in 71% of patients, with 44 (59%) receiving a combination of anti\u2010thymocyte globulin (ATG) and PTCy. The median follow\u2010up was 44.4\u2009months. Primary graft failure occurred in three patients (4%). The incidence of grade III\u2010IV acute GvHD at day 100 was 13% (95% CI: 6\u201322). At 2\u2009years, the incidence of moderate\u2013severe chronic GvHD, non\u2010relapse mortality (NRM), relapse, GvHD\u2010free\/relapse\u2010free survival (GRFS), and overall survival (OS) was 31.7% (95% CI 20.7\u201343.2), 37.9% (26\u201349), 17.4% (95% CI: 10\u201327), 24.8% (95% CI: 15\u201336), and 51.6% (95% CI: 39\u201363), respectively. PTCy\u2010based GvHD prophylaxis seemed to be associated with improved OS (HR: 0.5, 95% CI: 0.3\u20130.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), NRM (HR: 0.4, 95% CI: 0.2\u20130.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), and GRFS (HR: 0.5, 95% CI: 0.3\u20130.8, 0.009). On multivariable analysis, the use of the PTCy\u2010containing regimen seemed to be associated with improved NRM (HR: 0.41; 95% CI: 0.2\u20130.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), GRFS (HR: 0.47; 95% CI: 0.3\u20130.8;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009), and OS (HR: 0.49; 95% CI: 0.2\u20130.9;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) without an increased risk of relapse.\n                  <\/jats:p>","DOI":"10.1111\/ejh.14430","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T20:19:49Z","timestamp":1746649189000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation for Myelodysplastic\/Myeloproliferative Overlap Neoplasms"],"prefix":"10.1111","volume":"115","author":[{"given":"Nihar","family":"Desai","sequence":"first","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rodriguez\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4171-4678","authenticated-orcid":false,"given":"Tommy Alfaro","family":"Moya","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-4626","authenticated-orcid":false,"given":"Eshrak","family":"Al\u2010Shaibani","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Novitzky\u2010Basso","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7595-0113","authenticated-orcid":false,"given":"Ivan","family":"Pasic","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Hematology, Hans Messner Allogeneic Blood and Marrow Transplant Program Princess Margaret Cancer Centre  Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto  Toronto Ontario 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