{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:03:29Z","timestamp":1785776609012,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009663","name":"University Health Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperdiploid karyotype (HK) (49\u201365 chromosomes) in acute myeloid leukemia (AML) is rare. Recently, HK\u2010AML with only numerical changes has been reclassified into an intermediate risk group in the updated 2022 European LeukemiaNet (ELN) risk classification, which has historically been classified into an adverse risk group. However, there are limited data in the literature concerning whether these new exclusion criteria are appropriate, and the genetic landscape of HK\u2010AML remains unclear. We retrospectively analyzed a cohort of HK\u2010AML diagnosed at our institution. Among 124 cases, 72 (58.1%) had concurrent adverse risk cytogenetic abnormalities (HK\u2010ADV), 33 (26.6%) had other concurrent structural abnormalities (HK\u2010STR) and 19 (15.3%) had numerical changes alone (HK\u2010NUM). The most frequently gained chromosomes were chromosomes 8, 22, 21, and 19.\n                    <jats:italic>TP53<\/jats:italic>\n                    mutation was associated with HK\u2010ADV, and a higher frequency of mutations in DNA methylation genes was present in HK\u2010NUM and HK\u2010STR. Patients with HK\u2010NUM had significantly longer overall survival (OS) and event\u2010free survival (EFS) compared to those with HK\u2010ADV. In the adjusted model accounting for confounders, the HK\u2010STR outcome was superior to that of HK\u2010ADV but was not significantly different from that of HK\u2010NUM. In addition, patients with a modal chromosome number of 49\u201353 had more favorable survival than those with \u2265\u200954 chromosomes. Our data support the reclassification of HK\u2010NUM patients in the intermediate risk group and suggest that HK\u2010STR might also be more appropriately classified into the intermediate risk group.\n                  <\/jats:p>","DOI":"10.1111\/ejh.14434","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T01:50:12Z","timestamp":1747101012000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Landscape and Risk Stratification of\n                    <scp>AML<\/scp>\n                    With Hyperdiploid Karyotype"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9518-9879","authenticated-orcid":false,"given":"Ehsan","family":"Bahrami Hezaveh","sequence":"first","affiliation":[{"name":"Department of Laboratory Hematology University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davidson","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Hematology University Health Network  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collins","family":"Wangulu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario 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Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_11_3_1","unstructured":"F.Mitelman B.Johansson andF.Mertens \u201cMitelman Database of Chromosome Aberrations and Gene Fusions in Cancer \u201d(2025) 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