{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:07:21Z","timestamp":1770217641735,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The evolution of acute myeloid leukemia (AML) classifications has progressively shifted the diagnostic focus toward genetic criteria. Nevertheless, morphology remains a key element in clinical practice, often serving as the initial trigger for additional molecular investigations. The diagnosis of acute erythroleukemia (AEML), initially defined by the FAB group, is no longer recognized as a distinct entity in the latest WHO and ICC classifications. Some studies have indicated that AEML shares similarities with myelodysplastic neoplasms, including a high frequency of\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations and adverse karyotypes. Here, we conducted a retrospective analysis in adults with AEML defined using historical morphologic criteria (\u2265\u200950% erythroid precursors and \u2265\u200920% blasts among non\u2010erythroid cells). In contrast to older patients, young adults (18\u201360\u2009years) exhibit unique genetic profiles including a high prevalence of normal karyotypes (65%),\n                    <jats:italic>NPM1<\/jats:italic>\n                    (35%) and\n                    <jats:italic>UBTF<\/jats:italic>\n                    (23%) mutations. AEML morphology in\n                    <jats:italic>NPM1<\/jats:italic>\n                    \u2010mutated cases did not impact clinical outcomes but was associated with specific molecular features, including an enrichment of\n                    <jats:italic>WT1<\/jats:italic>\n                    and cohesin gene mutations. In this age group, our findings support that morphologically defined AEML often corresponds to AML according to current genetic criteria, consistent with recent classification systems that prioritize molecular features over morphology.\n                  <\/jats:p>","DOI":"10.1111\/ejh.14435","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:19:29Z","timestamp":1747282769000},"page":"185-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myeloid Neoplasms With Erythroid Predominance and Excess Blasts in Young Adults Exhibit Distinct Genetic Profiles"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2808-4843","authenticated-orcid":false,"given":"Laur\u00e8ne","family":"Fenwarth","sequence":"first","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-8694","authenticated-orcid":false,"given":"Benjamin","family":"Podvin","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9065-0477","authenticated-orcid":false,"given":"Lo\u00efc","family":"Vasseur","sequence":"additional","affiliation":[{"name":"Department of Hematology Saint Louis Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Lebon","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Couillez","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Berthon","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"},{"name":"Department of Hematology Claude Huriez Hospital, CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Caulier","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Fournier","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bories","sequence":"additional","affiliation":[{"name":"Department of Hematology CH Lens  Lens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Carpentier","sequence":"additional","affiliation":[{"name":"Department of Hematology St Vincent Hospital  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Tricot","sequence":"additional","affiliation":[{"name":"Department of Hematology CH Valenciennes  Valenciennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin\u2010James","family":"Wattebled","sequence":"additional","affiliation":[{"name":"Department of Hematology CH Dunkerque  Dunkerque France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Roche\u2010Lestienne","sequence":"additional","affiliation":[{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"},{"name":"Department of Medical Genetics Jeanne de Flandre Hospital, CHU Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin","family":"Lestringant","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Hauspie","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Celli\u2010Lebras","sequence":"additional","affiliation":[{"name":"Department of Hematology Saint Louis Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00ebl","family":"Heiblig","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospices Civils de Lyon  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Dombret","sequence":"additional","affiliation":[{"name":"Department of Hematology Saint Louis Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Itzykson","sequence":"additional","affiliation":[{"name":"Department of Hematology Saint Louis Hospital, AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Marolleau","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Gar\u00e7on","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Preudhomme","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-1022","authenticated-orcid":false,"given":"Nicolas","family":"Duployez","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology Centre Hospitalier Universitaire (CHU) de Lille  Lille France"},{"name":"Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020\u2010U1277\u2014Canther\u2014Cancer Heterogeneity, Plasticity and Resistance to Therapies  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8133-5491","authenticated-orcid":false,"given":"Thomas","family":"Boyer","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology CHU Amiens\u2010Picardie  Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Un caso di eritroleucemia. 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