{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T06:56:51Z","timestamp":1786863411543,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Though evidence suggests that multiple myeloma (MM) in adolescents and young adults (AYA) (&lt;\u200950\u2009years) has significant biological differences from that in older individuals (\u2265\u200950\u2009years), the understanding of the disease in this group is limited. We examined the outcomes in AYA hospitalizations with MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the National Inpatient Sample database, we examined sociodemographic, hospital\u2010level, and clinical characteristics between AYA and older populations with MM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 183\u2009846 non\u2010elective MM hospitalizations, 13\u2009765 (7.5%) were AYA. There was a higher proportion of males in the AYA group compared to the older group (58.6% vs. 54.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but a lower distribution of non\u2010Hispanic Whites (40.6% vs. 56.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The AYA group had lower odds of mortality (aOR: 0.59, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) relative to the older adult group. They were more likely to receive autologous stem cell transplantation (aOR: 1.80, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but had similar odds of acute venous thromboembolism (aOR: 0.87; <jats:italic>p<\/jats:italic>\u2009=\u20090.24) and severe sepsis (aOR: 0.89; <jats:italic>p<\/jats:italic>\u2009=\u20090.52).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We highlight the unique characteristics and outcomes of AYA\u2010MM, emphasizing the need for their greater representation in clinical research. Additionally, we underscore the importance of further investigation to better understand and optimize survivorship care in AYA patients with MM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ejh.14437","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:14:52Z","timestamp":1747966492000},"page":"232-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics and Clinical Outcomes of Multiple Myeloma in Adolescents and Young Adults"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-747X","authenticated-orcid":false,"given":"Ayobami","family":"Olafimihan","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine John H. 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